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Boronic Acid Functionalized Nanosilica for Binding Guest Molecules
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2021-02-19 , DOI: 10.1021/acsanm.1c00005 Xiaoting Xue 1 , Haiyue Gong 1 , Hongwei Zheng 1 , Lei Ye 1
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2021-02-19 , DOI: 10.1021/acsanm.1c00005 Xiaoting Xue 1 , Haiyue Gong 1 , Hongwei Zheng 1 , Lei Ye 1
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Dendritic fibrous nanosilica (DFNS) has very high surface area and well-defined nanochannels; therefore, it is very useful as supporting material for numerous applications including catalysis, sensing, and bioseparation. Due to the highly restricted space, addition of molecular ligands to DFNS is very challenging. This work studies how ligand conjugation in nanoscale pores in DFNS can be achieved through copper-catalyzed click reaction, using an optional, in situ synthesized, temperature-responsive polymer intermediate. A clickable boronic acid is used as a model to investigate the ligand immobilization and the molecular binding characteristics of the functionalized DFNS. The morphology, composition, nanoscale pores, and specific surface area of the boronic acid functionalized nanosilica were characterized by electron microscopy, thermogravimetric and elemental analysis, Fourier transform infrared spectroscopy, and nitrogen adsorption–desorption measurements. The numbers of boronic acid molecules on the modified DFNS with and without the polymer were determined to be 0.08 and 0.68 mmol of ligand/g of DFNS, respectively. We also studied the binding of small cis-diol molecules in the nanoscale pores of DFNS. The boronic acid modified DFNS with the polymer intermediate exhibits higher binding capacity for Alizarin Red S and nicotinamide adenine dinucleotide than the polymer-free DFNS. The two types of boronic acid modified DFNS can bind small cis-diol molecules in the presence of large glycoproteins, due in large part to the effect of size exclusion provided by the nanochannels in the DFNS.
中文翻译：
硼酸官能化的纳米二氧化硅用于结合客体分子
树枝状纤维纳米二氧化硅（DFNS）具有非常高的表面积和明确的纳米通道。因此，它非常适合作为许多应用的支撑材料，包括催化，传感和生物分离。由于空间的高度限制，向DFNS添加分子配体非常具有挑战性。这项工作研究了如何使用可选的，原位合成的，对温度敏感的聚合物中间体，通过铜催化的点击反应，实现DFNS纳米级孔中的配体共轭。可点击的硼酸用作模型来研究功能化DFNS的配体固定和分子结合特性。用电子显微镜表征了硼酸官能化纳米二氧化硅的形貌，组成，纳米级孔和比表面积，热重和元素分析，傅立叶变换红外光谱和氮吸附-解吸测量。带有和不带有聚合物的改性DFNS上的硼酸分子数分别确定为0.08和0.68 mmol配体/ g DFNS。我们还研究了小绑定DFNS纳米孔中的顺式-二醇分子。与不含聚合物的DFNS相比，带有聚合物中间体的硼酸修饰的DFNS对茜素红S和烟酰胺腺嘌呤二核苷酸的结合能力更高。在大糖蛋白存在下，两种类型的硼酸修饰的DFNS可以结合小的顺式二醇分子，这在很大程度上归因于DFNS中纳米通道所提供的尺寸排阻作用。
更新日期：2021-03-26
中文翻译：
硼酸官能化的纳米二氧化硅用于结合客体分子
树枝状纤维纳米二氧化硅（DFNS）具有非常高的表面积和明确的纳米通道。因此，它非常适合作为许多应用的支撑材料，包括催化，传感和生物分离。由于空间的高度限制，向DFNS添加分子配体非常具有挑战性。这项工作研究了如何使用可选的，原位合成的，对温度敏感的聚合物中间体，通过铜催化的点击反应，实现DFNS纳米级孔中的配体共轭。可点击的硼酸用作模型来研究功能化DFNS的配体固定和分子结合特性。用电子显微镜表征了硼酸官能化纳米二氧化硅的形貌，组成，纳米级孔和比表面积，热重和元素分析，傅立叶变换红外光谱和氮吸附-解吸测量。带有和不带有聚合物的改性DFNS上的硼酸分子数分别确定为0.08和0.68 mmol配体/ g DFNS。我们还研究了小绑定DFNS纳米孔中的顺式-二醇分子。与不含聚合物的DFNS相比，带有聚合物中间体的硼酸修饰的DFNS对茜素红S和烟酰胺腺嘌呤二核苷酸的结合能力更高。在大糖蛋白存在下，两种类型的硼酸修饰的DFNS可以结合小的顺式二醇分子，这在很大程度上归因于DFNS中纳米通道所提供的尺寸排阻作用。
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