Skin-like flexible membrane with excellent water resistance and moisture permeability is an urgent need in the wound dressing field to provide comfort and protection for the wound site. Despite efforts that have been made in the development of waterproof and breathable (W&B) membranes, the in-situ electrospinning of W&B membranes suitable for irregular wound surfaces as wound dressings still faces huge challenges. In the current work, a portable electrospinning device with multi-functions, including adjustable perfusion speed for a large range from 0.05 mL/h to 10 mL/h and high voltage up to 11 kV, was designed. The thymol-loaded ethanol-soluble polyurethane (EPU) skin-like W&B nanofibrous membranes with antibacterial activity were fabricated via the custom-designed device. Ultimately, the resultant nanofibrous membranes composed of EPU, fluorinated polyurethane (FPU), and thymol presented uniform structure, robust waterproofness with the hydrostatic pressure of 17.6 cm H₂O, excellent breathability of 3.56 kg m⁻² d⁻¹, the high tensile stress of 1.83 MPa and tensile strain of 453%, as well as high antibacterial activity. These results demonstrate that the new-type device has potential as a portable electrospinning apparatus for the fabrication of antibacterial membranes directly on the wound surface and puts a new way for the development of portable electrospinning devices.

具有优异的耐水性和透湿性的皮肤状柔性膜是伤口敷料领域中的迫切需要，以为伤口部位提供舒适感和保护。尽管已在防水，透气（W＆B）膜的发展作出了努力，在原位由于伤口敷料仍面临巨大挑战，适用于不规则伤口表面的W＆B膜的静电纺丝。在目前的工作中，设计了一种多功能的便携式静电纺丝设备，包括可调节的灌注速度，可在0.05 mL / h至10 mL / h的较大范围内进行调节，并具有高达11 kV的高压。通过定制设计的装置，制备了具有百里香酚负载量的乙醇可溶性聚氨酯（EPU）皮肤形W＆B纳米纤维膜，具有抗菌活性。最终，由EPU，氟化聚氨酯（FPU）和百里香酚组成的纳米纤维膜呈现出均匀的结构，稳固的防水性和17.6 cm H ₂ O的静水压力，3.56 kg m ^-2 d ^-1的出色透气性，具有1.83 MPa的高拉伸应力和453％的拉伸应变，以及很高的抗菌活性。这些结果表明，该新型装置具有作为在伤口表面直接制造抗菌膜的便携式电纺丝设备的潜力，并为开发便携式电纺丝设备提供了新的途径。