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Recent Advances in Inorganic Chiral Nanomaterials
Advanced Materials ( IF 27.4 ) Pub Date : 2021-02-17 , DOI: 10.1002/adma.202005506
Junjun Liu 1, 2 , Lin Yang 1, 2 , Ping Qin 1, 3 , Shiqing Zhang 3, 4 , Ken Kin Lam Yung 3, 4 , Zhifeng Huang 1, 2, 3, 5
Affiliation  

Inorganic nanoparticles offer a multifunctional platform for biomedical applications in drug delivery, biosensing, bioimaging, disease diagnosis, screening, and therapies. Homochirality prevalently exists in biological systems composed of asymmetric biochemical activities and processes, so biomedical applications essentially favor the usage of inorganic chiral nanomaterials, which have been widely studied in the past two decades. Here, the latest investigations are summarized including the characterization of 3D stereochirality, the bionic fabrication of hierarchical chirality, extension of the compositional space to poly-elements, studying optical activities with the (sub-)single-particle resolution, and the experimental demonstration in biomedical applications. These advanced studies pave the way toward fully understanding the two important chiral effects (i.e., the chiroptical and enantioselective effects), and prospectively promote the flexible design and fabrication of inorganic chiral nanoparticles with engineerable functionalities to solve diverse practical problems closely associated with environment and public health.

中文翻译:

无机手性纳米材料的最新进展

无机纳米粒子为药物输送、生物传感、生物成像、疾病诊断、筛查和治疗中的生物医学应用提供了一个多功能平台。同手性普遍存在于由不对称生化活动和过程组成的生物系统中,因此生物医学应用本质上倾向于使用无机手性纳米材料,这在过去的二十年中得到了广泛的研究。在这里,总结了最新的研究,包括 3D 立体手性的表征、分层手性的仿生制造、将组成空间扩展到多元素、用(亚)单粒子分辨率研究光学活动,以及在生物医学应用。
更新日期:2021-02-17
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