The aim of this research is to confect Chloroxine-conjugated AgNPs (COX-AgNPs), employing an eco-friendly method. The conjugation of antibiotics and antibacterial drugs with nanoparticles demonstrates better biological activity compared to free antibacterial and antibiotic molecules. Therefore, our groups employed Echinophora platyloba DC extract to prepared silver nanoparticles and subsequent conjugation of them to antibacterial drug Chloroxine. We employed the analytical techniques (UV–vis, DLS, zeta potential, SEM-EDX, FT-IR, XRD, and TEM) to investigate the composition, morphology, and size of the green synthesized AgNPs and COX-AgNPs. Our synthesized AgNPs displayed a remarkable antibacterial and antifungal activity against various microorganisms. The green synthesized AgNPs reported in this work is relatively smaller than some green synthesized AgNPs reported in the literature. Moreover, the efficacy of AgNPs was elevated by conjugating the antibacterial drug Chloroxine to them. Also, our finding indicated that COX-AgNPs have potential to accelerate wound healing, which refers to the antibacterial and antifungal activity of COX-AgNPs.

这项研究的目的是采用一种生态友好的方法来完善与氯氧嘧啶偶联的AgNPs（COX-AgNPs）。与游离的抗菌和抗生素分子相比，抗生素和抗菌药物与纳米颗粒的结合表现出更好的生物学活性。因此，我们的研究小组采用了Echinophora platyloba DC提取物来制备银纳米颗粒，然后将它们与抗菌药物氯氧嘧啶结合。我们采用分析技术（紫外可见光，DLS，ζ电位，SEM-EDX，FT-IR，XRD和TEM）研究了绿色合成的AgNP和COX-AgNP的组成，形态和大小。我们合成的AgNP对各种微生物显示出显着的抗菌和抗真菌活性。在这项工作中报道的绿色合成的AgNPs相对小于文献中报道的一些绿色合成的AgNPs。此外，通过将抗菌药物氯氧嘧啶与它们结合可以提高AgNP的功效。同样，我们的发现表明，COX-AgNPs具有加速伤口愈合的潜力，这是指COX-AgNPs的抗菌和抗真菌活性。