The crystal structure of tamsulosin hydrochloride has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Tamsulosin hydrochloride crystallizes in space group P21 (#4) with a = 7.62988(2), b = 9.27652(2), c = 31.84996(12) Å, β = 93.2221(2)°, V = 2250.734(7) Å3, and Z = 4. In the crystal structure, two arene rings are connected by a carbon chain oriented roughly parallel to the c-axis. The crystal structure is characterized by two slabs of tamsulosin hydrochloride molecules perpendicular to the c-axis. As expected, each of the hydrogens on the protonated nitrogen atoms makes a strong hydrogen bond to one of the chloride anions. The result is to link the cations and anions into columns along the b-axis. One hydrogen atom of each sulfonamide group also makes a hydrogen bond to a chloride anion. The other hydrogen atom of each sulfonamide group forms bifurcated hydrogen bonds to two ether oxygen atoms. The powder pattern is included in the Powder Diffraction File™ as entry 00-065-1415.

中文翻译：

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盐酸坦洛新的晶体结构，C20H29N2O5SCl

使用同步加速器 X 射线粉末衍射数据对盐酸坦洛新的晶体结构进行了求解和改进，并使用密度泛函技术进行了优化。盐酸坦洛新在空间群中结晶磷21(#4) 与一种= 7.62988(2),b= 9.27652(2),C= 31.84996(12) 埃，β= 93.2221(2)°,五= 2250.734(7) Å3， 和Z= 4. 在晶体结构中，两个芳烃环通过大致平行于C-轴。晶体结构的特点是两片盐酸坦洛新分子垂直于C-轴。正如预期的那样，质子化氮原子上的每个氢都与氯阴离子之一形成强氢键。结果是将阳离子和阴离子连接成沿b-轴。每个磺酰胺基团的一个氢原子也与氯阴离子形成氢键。每个磺酰胺基团的另一个氢原子与两个醚氧原子形成分叉的氢键。粉末图案作为条目 00-065-1415 包含在 Powder Diffraction File™ 中。