Gold Nanoclusters Perform Enzyme-like Photocatalysis for Prodrug Activation,ACS Applied Nano Materials

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Gold Nanoclusters Perform Enzyme-like Photocatalysis for Prodrug Activation
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2021-02-12 , DOI: 10.1021/acsanm.1c00014
Rong Liu ₁ , Dajiao Cheng ₁ , Quan Zhou ₁ , Fushuang Niu ₁ , Ke Hu ₁

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Many synthetic nanomaterials known as nanozymes can catalyze biologically relevant molecular transformations just as natural enzyme does. “Photonanozyme” utilizes light as a spatial and temporal control for the regulation of nanozyme activities. Here we report a glutathione-modified gold nanocluster as a photonanozyme that catalyzes the reduction of nitrobenzene under light. Aniline was found as the sole photoreductive product. The photocatalytic reactions at variable light fluences were found to follow the classical Michaelis–Menten enzyme kinetics from which kinetic rate constants were quantified. Intracellular reduction of a nitro-group-containing fluorescent probe demonstrates the viability of gold nanoclusters as biocompatible photonanozymes performing catalysis in a mammalian cell environment. This study reinvents gold nanoclusters as photonanozymes that mimic naturally occurring nitroreductase for potential prodrug activation.

中文翻译：

金纳米簇执行类似酶的光催化作用以激活前药

与天然酶一样，许多被称为纳米酶的合成纳米材料可以催化生物学上相关的分子转化。“光纳米酶”利用光作为用于调节纳米酶活性的空间和时间控制。在这里，我们报道了一种谷胱甘肽修饰的金纳米团簇，它是一种光纳米酶，能在光下催化硝基苯的还原。发现苯胺是唯一的光还原产品。发现在可变光通量下的光催化反应遵循经典的Michaelis-Menten酶动力学，从中可以定量动力学速率常数。含硝基基团荧光探针的细胞内还原表明，金纳米簇作为生物相容性光合酶在哺乳动物细胞环境中进行催化的可行性。

更新日期：2021-02-26

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