Molecular Diversity ( IF 3.9 ) Pub Date : 2021-02-11 , DOI: 10.1007/s11030-021-10194-7 Sana Sikandar 1 , Ameer Fawad Zahoor 1 , Shazia Naheed 1 , Bushra Parveen 1 , Kulsoom Ghulam Ali 1 , Rabia Akhtar 1
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Fukuyama reaction for the synthesis of multifunctional aldehydes, secondary amines and ketones has gained considerable importance in synthetic organic chemistry because of mild reaction conditions. The use of thioesters in both Fukuyama aldehydes and ketones synthesis is highly attractive for organic chemists as they are easily accessible from corresponding carboxylic acids. Fukuyama–Mitsunobu reaction utilizes 2-nitrobenzenesulfonyl (Ns) for the protection/activation/deprotection of primary amines to afford secondary amines in good yields and high enantioselectivities. This review presents recent synthetic developments and applications of Fukuyama reaction for the synthesis of aldehydes, secondary amines and ketones.
Graphic abstract
中文翻译：
福山还原、福山偶联和福山-光信烷基化：最新进展和合成应用
由于反应条件温和，用于合成多功能醛、仲胺和酮的福山反应在有机合成化学中具有相当重要的意义。在福山醛和酮合成中使用硫酯对有机化学家来说非常有吸引力，因为它们很容易从相应的羧酸中获得。Fukuyama-Mitsunobu 反应利用 2-硝基苯磺酰基 (Ns) 对伯胺进行保护/活化/去保护，从而以良好的收率和高对映选择性得到仲胺。本综述介绍了 Fukuyama 反应在合成醛、仲胺和酮方面的最新进展和应用。
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