Abstract

An efficient rapid synthesis of a new class of diversely functionalized 6-phenyl-3-(1H-pyrazol-1-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a–q) is described via a facile one-pot, three-component cascade reaction with high yields. It is a multi-functional cyclization reaction to form two new heterocycles. The structures of newly formed compounds were confirmed by using spectral and analytical studies. Simple reaction conditions, the good isolated yield of the product, and no column chromatographic purification are attractive features of the present protocol. Further, the newly synthesized compounds were screened for anti-microbial activity and molecular docking interactions.

摘要

一种新型多官能化6-苯基-3-(1H-吡唑-1-基)-[1,2,4]三唑并[3,4-b][1,3,4]噻二唑的高效快速合成衍生物 ( 4a-q ) 通过简单的一锅三组分级联反应进行描述，产率高。它是形成两个新杂环的多功能环化反应。通过光谱和分析研究证实了新形成的化合物的结构。简单的反应条件、良好的产物分离收率和无柱层析纯化是本协议的吸引人的特点。此外，筛选了新合成的化合物的抗微生物活性和分子对接相互作用。