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Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics
Advanced Materials ( IF 27.4 ) Pub Date : 2021-02-09 , DOI: 10.1002/adma.202005062
Hui Hu 1, 2 , Wei Feng 3 , Xiaoqin Qian 1 , Luodan Yu 3 , Yu Chen 3, 4 , Yuehua Li 2
Advanced Materials ( IF 27.4 ) Pub Date : 2021-02-09 , DOI: 10.1002/adma.202005062
Hui Hu 1, 2 , Wei Feng 3 , Xiaoqin Qian 1 , Luodan Yu 3 , Yu Chen 3, 4 , Yuehua Li 2
Affiliation
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The rapid knowledge growth of nanomedicine and nanobiotechnology enables and promotes the emergence of distinctive disease‐specific therapeutic modalities, among which nanomedicine‐enabled/augmented nanodynamic therapy (NDT), as triggered by either exogenous or endogenous activators on nanosensitizers, can generate reactive radicals for accomplishing efficient disease nanotherapies with mitigated side effects and endowed disease specificity. As one of the most representative modalities of NDT, traditional light‐activated photodynamics suffers from the critical and unsurmountable issues of the low tissue‐penetration depth of light and the phototoxicity of the photosensitizers. To overcome these obstacles, versatile nanomedicine‐enabled/augmented NDTs have been explored for satisfying varied biomedical applications, which strongly depend on the physicochemical properties of the involved nanomedicines and nanosensitizers. These distinctive NDTs refer to sonodynamic therapy (SDT), thermodynamic therapy (TDT), electrodynamic therapy (EDT), piezoelectric dynamic therapy (PZDT), pyroelectric dynamic therapy (PEDT), radiodynamic therapy (RDT), and chemodynamic therapy (CDT). Herein, the critical roles, functions, and biological effects of nanomedicine (e.g., sonosensitizing, photothermal‐converting, electronic, piezoelectric, pyroelectric, radiation‐sensitizing, and catalytic properties) for enabling the therapeutic procedure of NDTs, are highlighted and discussed, along with the underlying therapeutic principle and optimization strategy for augmenting disease‐therapeutic efficacy and biosafety. The present challenges and critical issues on the clinical translations of NDTs are also discussed and clarified.
中文翻译:
超越传统光动力学的新兴纳米医学启用/增强的纳米动力学疗法
纳米医学和纳米生物技术知识的快速增长使得并促进了独特的疾病特异性治疗方式的出现,其中纳米医学支持/增强的纳米动力疗法(NDT),由纳米敏化剂上的外源性或内源性激活剂触发,可以产生反应自由基实现有效的疾病纳米疗法,减轻副作用并赋予疾病特异性。作为无损检测最具代表性的方式之一,传统的光激活光动力技术面临着光的组织穿透深度低和光敏剂的光毒性等关键且难以克服的问题。为了克服这些障碍,人们已经探索了多功能的纳米医学支持/增强的无损检测,以满足各种生物医学应用,这些应用在很大程度上取决于所涉及的纳米药物和纳米敏化剂的物理化学性质。这些独特的无损检测是指声动力疗法(SDT)、热动力疗法(TDT)、电动力疗法(EDT)、压电动力疗法(PZDT)、热释电动力疗法(PEDT)、放射动力疗法(RDT)和化学动力疗法(CDT)。在此,强调并讨论了纳米医学(例如声敏、光热转换、电子、压电、热电、辐射敏化和催化特性)对于实现无损检测治疗过程的关键作用、功能和生物效应,以及具有增强疾病治疗功效和生物安全性的基本治疗原理和优化策略。还讨论并阐明了无损检测临床转化当前的挑战和关键问题。
更新日期:2021-03-23
中文翻译:
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超越传统光动力学的新兴纳米医学启用/增强的纳米动力学疗法
纳米医学和纳米生物技术知识的快速增长使得并促进了独特的疾病特异性治疗方式的出现,其中纳米医学支持/增强的纳米动力疗法(NDT),由纳米敏化剂上的外源性或内源性激活剂触发,可以产生反应自由基实现有效的疾病纳米疗法,减轻副作用并赋予疾病特异性。作为无损检测最具代表性的方式之一,传统的光激活光动力技术面临着光的组织穿透深度低和光敏剂的光毒性等关键且难以克服的问题。为了克服这些障碍,人们已经探索了多功能的纳米医学支持/增强的无损检测,以满足各种生物医学应用,这些应用在很大程度上取决于所涉及的纳米药物和纳米敏化剂的物理化学性质。这些独特的无损检测是指声动力疗法(SDT)、热动力疗法(TDT)、电动力疗法(EDT)、压电动力疗法(PZDT)、热释电动力疗法(PEDT)、放射动力疗法(RDT)和化学动力疗法(CDT)。在此,强调并讨论了纳米医学(例如声敏、光热转换、电子、压电、热电、辐射敏化和催化特性)对于实现无损检测治疗过程的关键作用、功能和生物效应,以及具有增强疾病治疗功效和生物安全性的基本治疗原理和优化策略。还讨论并阐明了无损检测临床转化当前的挑战和关键问题。