Osseointegration: Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis (Adv. Funct. Mater. 7/2021),Advanced Functional Materials

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Osseointegration: Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis (Adv. Funct. Mater. 7/2021)
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-02-10 , DOI: 10.1002/adfm.202170043
Zhenzhen Wang _{1,

2} , Yiming Niu _{1,

2} , Xuejiao Tian ₂ , Na Yu ₃ , Xiaoyu Yin ₁ , Zhen Xing ₂ , Yurong Li ₂ , Lei Dong _{2,

4} , Chunming Wang ₁

Affiliation

In article number 2007408, Lei Dong, Chunming Wang, and co‐workers invent a “bridge‐burning” bioactive coating to sequentially turn on and off inflammation on bone implants. This coating first instructs host macrophages to activate bone cells to promote healing and then receives signals from bone cells to kill macrophages for higher safety. It improves bone‐implant integration in mice with osteoporosis.

中文翻译：

骨整合：通过“桥烧”涂层开启和关闭巨噬细胞可改善骨质疏松症下的骨植入物整合（高级功能材料7/2021）

在编号2007408中，董磊，王春明及其同事发明了一种“桥烧式”生物活性涂层，以依次打开和关闭骨植入物上的炎症。这种涂层首先指示宿主巨噬细胞激活骨细胞以促进愈合，然后从骨细胞接收信号杀死巨噬细胞以提高安全性。它可以改善骨质疏松症小鼠的骨植入整合性。

更新日期：2021-02-10

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