Isobavachalcone (IBC), a naturally occurring chalcone, is mainly isolated from the seeds of Psoralea corylifolia Linn. IBC demonstrates multiple pharmacological activities, including anti-cancer, anti-microbial, anti-inflammatory, antioxidative, neuroprotective, and among others. Several potential targets of IBC, such as AKT, dihydroorotate dehydrogenase (DHODH), have been identified. The pharmacokinetic profiles of IBC have been reported as well. In this review, the pharmacological activities, the underlying mechanisms, the potential targets, and the pharmacokinetic profiles of IBC were summarized. IBC might be a promising lead compound for drug discovery.

异巴伐查酮 (IBC) 是一种天然存在的查耳酮，主要从Psoralea corylifolia Linn的种子中分离出来。IBC 具有多种药理活性，包括抗癌、抗微生物、抗炎、抗氧化、神经保护等。已经确定了 IBC 的几个潜在目标，例如 AKT、二氢乳清酸脱氢酶 (DHODH)。IBC 的药代动力学特征也有报道。在这篇综述中，总结了 IBC 的药理活性、潜在机制、潜在靶点和药代动力学特征。IBC 可能是一种很有前途的药物发现先导化合物。