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Modular and Divergent Syntheses of Protoberberine and Protonitidine Alkaloids
Organic Letters ( IF 4.9 ) Pub Date : 2021-02-08 , DOI: 10.1021/acs.orglett.0c04310
Kai Liu 1 , Xuefeng Jiang 1, 2
Affiliation  

A modularly convergent and divergent strategy was established for the family synthesis of both protoberberine and protonitidine alkaloids. The robust, scalable, and flexible synthetic route featured a collective preparation of protoberberine and protonitidine alkaloids from a common isoquinoline assembled from pyridyne as the key synthon, which was based on the selective N–C or C–C cyclization via distinct processes. Through the strategy, 20 protoberberine alkaloids, 5 protonitidine alkaloids, and 11 analogues with diverse substituents were comprehensively aquired.

中文翻译:

小ber碱和质子碱生物碱的模块和发散合成

建立了模块化的收敛和发散策略,用于原小ber碱和质子碱生物碱的家族合成。健壮,可扩展且灵活的合成路线的特征是,由吡啶炔装配的常见异喹啉作为关键合成子,共同制备原小ber碱和质子碱生物碱,这是基于通过不同过程进行的选择性N-C或C-C环化。通过该策略,全面获得了20个原小ber碱生物碱,5个质子碱生物碱和11个具有不同取代基的类似物。
更新日期:2021-02-19
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