Treatment of N-(o-arylethynyl)benzyl p-toluenesulfonamides with molecular iodine in the presence of NaHCO₃ at 60 °C, followed by the reaction with ^tBuOK at room temperature gave 3-aryl-4-iodoisoquinolines in good yields. 4-Iodo-3-phenylisoquinoline, which is one of the obtained 3-aryl-4-iodoisoquinolines, was further transformed into isoquinoline derivatives smoothly. The present approach is a novel one-pot method for the preparation of 3-aryl-4-iodoisoquinolines from N-(o-arylethynyl)benzyl p-toluenesulfonamides under transition-metal-free conditions. © 2021 Elsevier Science. All rights reserved.

中文翻译：

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从N-（o-芳基乙炔基）苄基对甲苯磺酰胺与碘和碱轻松制备3-芳基-4-碘异喹啉

在60℃下在NaHCO ₃存在下用分子碘处理N-（邻-芳基乙炔基）苄基对甲苯磺酰胺，然后在室温下与^t BuOK反应，以良好的收率得到3-芳基-4-碘异喹啉。将得到的3-芳基-4-碘异喹啉之一的4-碘-3-苯基异喹啉进一步平滑地转化为异喹啉衍生物。本方法是在无过渡金属的条件下由N-（邻-芳基乙炔基）苄基对甲苯磺酰胺制备3-芳基-4-碘异喹啉的一锅法。©2021爱思唯尔科学。版权所有。