Cryptotanshinone (IUPAC name: (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione), a biologically active constituent extracted from the roots and rhizomes of the plant Salvia miltiorrhiza, has been studied in depth as a medicinally active compound and shown to have efficacy in the treatment of numerous diseases and disorders. In this review, we describe in detail the current status of cryptotanshinone research, including findings relating to the structure, pharmacokinetics, pharmacological activity, and derivatives of this compound. Cryptotanshinoneh as a diverse range of pharmacological effects, including anti-cancer, anti-inflammatory, immune regulatory, neuroprotective, and anti-fibrosis activities. Studies on the molecular mechanisms underlying the activities of cryptotanshinone have established that the JAK2/STAT3, PI3K/AKT, NF-κB, AMPK, and cell cycle pathways are involved in the inhibitory and pro-apoptotic effects of cryptotanshinone on different tumor cell lines, these molecular pathways interact in a coordinated manner to inhibit cell proliferation, migration and invasion,and induce transformation, autophagy, necrosis, and cellular immunity. The anti-inflammatory mechanisms of cryptotanshinone have been found to be associated with the TLR4-MyD88/PI3K/Nrf2 and TLR4-MyD88/NF-κB/MAPK pathways, whereasthe Hedgehog, NF-κB, and Nrf-2/HO-1 pathways are regulated by cryptotanshinone to reduce organ fibrosis, and its inhibitory effects on the PI3K/AKT-eNOS pathway have been linked to neuroprotective effects. Given the potential medicinal utility of cryptotanshinone, further research is needed to verify the efficacy and safety of this compound in clinical use, evaluate its pharmacological activity, and identify molecular targets.

隐丹参酮（IUPAC名称：（R）-1,2,6,7,8,9-六氢-1,6,6-三甲基菲（1,2-b）呋喃-10,11-二酮），一种从根部提取的生物活性成分，丹参植物的根茎作为一种药用活性化合物已得到深入研究，并显示出对多种疾病和病症的治疗功效。在这篇综述中，我们详细描述了隐丹参酮研究的当前状态，包括与该化合物的结构，药代动力学，药理活性和衍生物有关的发现。Cryptotanshinoneh具有多种药理作用，包括抗癌，抗炎，免疫调节，神经保护和抗纤维化活性。有关隐丹参酮活性的分子机制研究表明，JAK2 / STAT3，PI3K / AKT，NF-κB，AMPK，细胞周期途径参与隐丹参酮对不同肿瘤细胞系的抑制和促凋亡作用，这些分子途径以协同方式相互作用，抑制细胞增殖，迁移和侵袭，并诱导转化，自噬，坏死和细胞免疫。已发现隐丹参酮的抗炎机制与TLR4-MyD88 / PI3K / Nrf2和TLR4-MyD88 /NF-κB/ MAPK途径有关，而Hedgehog，NF-κB和Nrf-2 / HO-1途径则与之相关。它们受隐丹参酮调节以减少器官纤维化，并且其对PI3K / AKT-eNOS途径的抑制作用与神经保护作用有关。鉴于隐丹参酮的潜在医学用途，需要进一步研究以验证该化合物在临床上的功效和安全性，