Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C. Sm. have led to the isolation of fourteen undescribed 2,2′-cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu S, with twenty-seven previously described lignan analogues. Their structures and absolute configurations of heilaohuguosus A-S were established by spectroscopic methods including 1D and 2D-NMR techniques and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity against APAP-induced toxicity in HepG-2 cells, four 2,2′-cyclolignans, heilaohuguosus A and L, tiegusanin I and kadsuphilol I showed good hepatoprotective activities against APAP toxicity in HepG-2 cells with cell survival rates of 53.5 ± 1.7%, 55.2 ± 1.2%, 52.5 ± 2.4%, and 54.0 ± 2.2% (positive control bicyclol, 52.1 ± 1.3%) at 10 μM, respectively.

香球果新鲜果实的植物化学研究（Lem。）AC Sm。已经分离出十四种未描述的2,2'-环木脂素，称为heilaohuguosus AN，四种未描述的芳基四氢萘木脂素，heilaohuguosus OR和一种四氢呋喃木脂素，heilaohuguosu S，与先前描述的二十七种木脂素类似物。通过包括1D和2D-NMR技术以及CD实验在内的光谱方法，确定了它们的结构和绝对构型。评估了所有分离的化合物对HepG-2细胞中APAP诱导的毒性的肝保护活性，四个2，2'-环木脂素，黑毛果A和L，铁绿素I和kadsuphilol I对HepG-2细胞中APAP毒性具有良好的肝保护活性。细胞存活率分别为53.5±1.7％，55.2±1.2％，52.5±2.4％和54.0±2.2％（阳性对照双环醇为52.1±1。 μ男，分别。