Thirty-three new 2, 3-dihydroquinolin-4(1H)-one analogues were designed, synthesized and characterized by IR, ¹H NMR, ¹³C NMR and HRMS. The crystal structures of compounds 2g and 4l were characterized by single crystal X-ray diffraction. Their antifungal activities were determined against five plant pathogenic fungi namely Rhizoctonia solani, Fusarum graminearum, Helminthosporium maydis, Sclerotinia sclerotiorum and Botrytis cinerea. The results indicated that most of them revealed significant antifungal activity at 20 mg/L. Compound 4e showed the strongest antifungal activity against Botrytis cinerea and had better effects than the commercial fungicide fluopyram. Meanwhile, the active compounds were evaluated for their inhibitory activities against succinate dehydrogenase (SDH). The results displayed that they exhibited excellent activity. Compound 4e had better inhibitory activity than fluopyram. The molecular modeling results demonstrated that compound 4e could strongly bind to and interact with the binding sites of SDH. The inhibitory activity of 2, 3-dihydroquinolin-4(1H)-one derivatives against SDH has been reported for the first time.

设计，合成和鉴定了33个新的2，3-二氢喹啉-4（1 H）-one类似物，并通过IR，¹ H NMR，¹³ C NMR和HRMS进行了表征。化合物2g和4l的晶体结构通过单晶X射线衍射表征。他们的抗真菌活性对五种植物病原真菌即确定纹枯病，Fusarum菌，长蠕玉米小斑病，菌核病和灰霉病。结果表明，它们中的大多数在20 mg / L时显示出显着的抗真菌活性。化合物4e表现出对灰葡萄孢的最强抗真菌活性，并且比市售杀菌剂氟吡草胺具有更好的效果。同时，评估活性化合物对琥珀酸脱氢酶（SDH）的抑制活性。结果显示它们表现出优异的活性。化合物4e具有比氟吡兰更好的抑制活性。分子建模结果表明，化合物4e可与SDH的结合位点牢固结合并相互作用。首次报道了2，3-二氢喹啉-4（1 H）-one衍生物对SDH的抑制活性。