The blood–brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over time, allowing the enhancement of the drug’s therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs.

中文翻译：

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超声引导的持久发光纳米复合材料对胶质母细胞瘤细胞在脑组织中的治疗作用的长期近红外信号跟踪。

血脑屏障（BBB）是一种物理屏障，可以选择性地阻止某些物质通过血液进入大脑。BBB保护大脑免受细菌侵害，并导致颅内治疗困难。嵌入纳米气泡（NBs）并与持久性发光纳米颗粒（PLNs）结合的化疗药物替莫唑胺（TMZ）已用于通过图像跟踪有效治疗胶质母细胞瘤（GBM）。通过超声波感应，NB会产生气蚀，从而暂时打开血脑屏障。此外，PLN释放近红外发射和余辉，可以穿透深层组织并改善生物图像的信噪比。在这项工作中，随着时间的推移，纳米系统越过BBB进行药物递送和图像跟踪，从而增强了药物对GBM的治疗效果。