Urolithin is a metabolite of a class of compounds known as polyphenolswhich are found in various fruits, including pomegranates, nuts and strawberries. Urolithin is a biologically-active compound which has anti-inflammatory, antioxidant and anticancer properties. Our laboratory has focused on the use of a palladium-catalyzed intramolecular biaryl coupling reaction to yield urolithin C 3-glucuronide (uro-C 3-glur). The total synthesis of uro-C 3-glur has been accomplished in 11 steps starting from the commercially-available 3,4-dimethoxybenzaldehyde. We now report full details of the total synthesis of urolithin C 3-glucuronide (1).


中文翻译：

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尿石蛋白C 3-葡糖醛酸的全合成

尿石素是一类称为多酚的化合物的代谢产物，存在于多种水果中，包括石榴，坚果和草莓。Urolithin是生物-其具有抗炎，抗氧化和抗癌性质的活性化合物。我们的实验室致力于使用钯催化的分子内联芳基偶联反应生成尿石素C 3-葡糖醛酸（uro-C 3-glur）。从市售的3,4-二甲氧基苯甲醛开始，uro-C 3-浆料的总合成已通过11个步骤完成。现在，我们报告尿石素C 3-葡萄糖醛酸（1 ）的总合成的完整细节。