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Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2008 Mar 1 , DOI: 10.1016/j.bmc.2007.11.039 Yu-Cheng Chang 1 , Jayatilake Herath , Tony H-H Wang , Christine S Chow
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2008 Mar 1 , DOI: 10.1016/j.bmc.2007.11.039 Yu-Cheng Chang 1 , Jayatilake Herath , Tony H-H Wang , Christine S Chow
Affiliation
A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation.
中文翻译:
3-取代尿苷和假尿苷衍生物的合成和溶液构象研究。
合成了一系列基于天然存在的 3-(3-amino-3-carboxypropyl) 修饰的 3-取代尿苷和假尿苷衍生物。它们的水溶液构象是通过使用圆二色性和核磁共振光谱确定的。显示官能团组成和链长对修饰的核苷的顺/反构象的分布只有细微的影响。决定核苷构象的主要因素似乎是糖苷键(C-与N-糖苷)。
更新日期:2017-01-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
3-取代尿苷和假尿苷衍生物的合成和溶液构象研究。
合成了一系列基于天然存在的 3-(3-amino-3-carboxypropyl) 修饰的 3-取代尿苷和假尿苷衍生物。它们的水溶液构象是通过使用圆二色性和核磁共振光谱确定的。显示官能团组成和链长对修饰的核苷的顺/反构象的分布只有细微的影响。决定核苷构象的主要因素似乎是糖苷键(C-与N-糖苷)。