Highly Enantioselective Addition of N-2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Highly Enantioselective Addition of N-2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-01-27 , DOI: 10.1021/acs.joc.0c02511
Jie Chen ₁ , Dong-Yu Zhu ₁ , Xue-Jing Zhang ₁ , Ming Yan ₁

Affiliation

An enantioselective Michael addition between N-2,2,2-trifluoroethylisatin ketimines and ethylene sulfonyl fluoride has been disclosed. This method provides a facile strategy to access a range of structurally diverse isatin-derived α-(trifluoromethyl)imine derivatives with excellent yields and enantioselectivities. The intriguing combination of α-(trifluoromethyl)amine and sulfonyl fluoride groups leads to the valuable candidates for the drug discovery.

中文翻译：

N -2,2,2-三氟乙基Isatin Ketimines对乙烯磺酰氟的高度对映选择性加成

已经公开了在N -2,2,2-三氟乙基异丁酮酮与亚乙基磺酰氟之间的对映选择性迈克尔加成。该方法提供了一种简便的策略，可以以优异的收率和对映选择性来获得一系列结构多样的伊斯丁衍生的α-（三氟甲基）亚胺衍生物。α-（三氟甲基）胺和磺酰氟基团的有趣组合为药物发现提供了有价值的候选物。

更新日期：2021-02-05

点击分享查看原文

点击收藏

阅读更多本刊新发论文