Asymmetric α-Hydroxylation of α-Aryl-δ-lactams with Molecular Oxygen under Phase-Transfer Conditions,Organic Letters

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Asymmetric α-Hydroxylation of α-Aryl-δ-lactams with Molecular Oxygen under Phase-Transfer Conditions
Organic Letters ( IF 4.9 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.orglett.0c04022
Tomoaki Inukai ₁ , Taichi Kano ₁ , Keiji Maruoka _{2,

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Affiliation

An asymmetric synthesis of α-aryl-α-hydroxy-δ-lactams via phase-transfer-catalyzed hydroxylation with molecular oxygen is described. High yields and high enantioselectivities were achieved using 2,2-diarylvinyl group as an achiral auxiliary. This strategy allows facile access to α-aryl-α-hydroxy-δ-lactam derivatives containing a chiral quaternary center.

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