Decarboxylative C(sp3)–N Cross-Coupling of Diacyl Peroxides with Nitrogen Nucleophiles,Organic Letters

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Decarboxylative C(sp3)–N Cross-Coupling of Diacyl Peroxides with Nitrogen Nucleophiles
Organic Letters ( IF 4.9 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.orglett.0c04203
Zi-Liang Tang ₁ , Xuan-Hui Ouyang ₁ , Ren-Jie Song _{1,

2} , Jin-Heng Li _{1,

2,

3}

Affiliation

We have disclosed a new radical-mediated decarboxylative C(sp³)–N cross-coupling of diacyl peroxides with nitrogen nucleophiles. The primary and secondary alkyl radicals derived from corresponding diacyl peroxides were generated by copper catalysis or by merging copper catalysis and photoredox catalysis, respectively. Various N-alkyl nitrogen nucleophiles, including indazoles, triazoles, indoles, purine, carbazole, anilines, and sulfonamide, were provided with a broad substrate scope and good functional group tolerance.

中文翻译：

二酰基过氧化物与氮亲核试剂的脱羧 C(sp3)–N 交叉偶联

我们已经公开了一种新的自由基介导的脱羧 C(sp ³ )-N 交叉偶联二酰基过氧化物与氮亲核试剂。由相应的二酰基过氧化物衍生的伯和仲烷基分别通过铜催化或合并铜催化和光氧化还原催化产生。各种N-烷基氮亲核试剂，包括吲唑、三唑、吲哚、嘌呤、咔唑、苯胺和磺酰胺，具有广泛的底物范围和良好的官能团耐受性。

更新日期：2021-02-05

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