Zn-MOF-74 nanorods with uniform diameters of about 200 nm were successfully prepared by a triethylamine (TEA) assistant solvothermal method. The effects of TEA on the sizes and morphologies of nanoscale particles were investigated. Guided by this method, bimetallic Zn_xMn_1-x-MOF-74s were facilely prepared to endow the nanomaterial with magnetic resonance imaging (MRI) ability. Nanoscale Zn_0.7Mn_0.3-MOF-74 were successfully produced with homogenous Mn dispersion. Magnetic resonance relaxivity studies using clinical MRI equipment proved that Zn_0.7Mn_0.3-MOF-74 nanoparticles show a satisfactory r₁ relaxivity value of 6.5 mM⁻¹ s⁻¹. The saturated DOX loading capacity of Zn_0.7Mn_0.3-MOF-74 nanocarriers was evaluated to 113 mg g⁻¹. After chitosan (CS) coating, cytotoxicity experiments showed that DOX@Zn_0.7Mn_0.3-MOF-74@CS nanocomposites featured adequate biotolerability and no interference with cellular metabolism. These results indicated great potential of the bimetallic ZnMn-MOF-74s as new biomedical materials integrating cellular drug delivery with MR imaging applications.

通过三乙胺（TEA）辅助溶剂热法成功制备了直径约200 nm的Zn-MOF-74纳米棒。研究了TEA对纳米级颗粒尺寸和形貌的影响。在这种方法的指导下，轻松制备了双金属Zn _x Mn _1-x -MOF-74s，使纳米材料具有磁共振成像（MRI）能力。具有均匀的Mn分散体成功制备了纳米级Zn _0.7 Mn _0.3 -MOF-74。使用临床MRI设备进行的磁共振弛豫研究表明，Zn _0.7 Mn _0.3 -MOF-74纳米颗粒显示出令人满意的r ₁弛豫值6.5 mM ^-1 s^-1。Zn _0.7 Mn _0.3 -MOF-74纳米载体的饱和DOX负载能力评估为113 mg g ^-1。壳聚糖（CS）涂层后，细胞毒性实验表明DOX @ Zn _0.7 Mn _0.3 -MOF-74 @ CS纳米复合材料具有足够的生物耐受性，并且不干扰细胞代谢。这些结果表明双金属ZnMn-MOF-74s作为将细胞药物递送与MR成像应用相结合的新型生物医学材料具有巨大的潜力。