Benzoperylene-grafted and Cu2+ chelated polymeric nanoparticles for GSH depletion and chemodynamic therapy,Materials Chemistry Frontiers

当前位置： X-MOL 学术 › Mater. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Benzoperylene-grafted and Cu2+ chelated polymeric nanoparticles for GSH depletion and chemodynamic therapy
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2021-1-7 , DOI: 10.1039/d0qm00835d
Niu Niu _{1,

2,

3,

4,

5} , Huipeng Zhou _{1,

2,

3,

4,

5} , Na Yang _{1,

2,

3,

4,

5} , Dong Wang _{6,

7,

8,

9,

10} , Cong Yu _{1,

2,

3,

4,

5}

Affiliation

Polymeric nanoparticles that can respond to a specific tumor microenvironment (TME) show great potential as anticancer agents. In this study, a highly water-soluble polymeric nanoparticle BPP was obtained via atom transfer radical polymerization (ATRP). The strong tendency of self-aggregation of the grafted aromatic benzoperylene facilitated the self-assembly of the polymer into nanoparticles. BPP showed strong excimer emission and could chelate with various metal ions with quenched emission. Cu²⁺ was then chelated with BPP to form BPC nanoparticles, which were subsequently used as chemodynamic therapy agents. After entering into the cancer cells, BPC could deplete GSH and produce Cu⁺. Cu⁺ reacted with intracellular H₂O₂ and generated toxic hydroxyl radicals (˙OH) via the Fenton-like reaction, which had a fast reaction rate in TME. Because of the high GSH and H₂O₂ concentrations in tumor cells, BPC NPs exhibited selective cytotoxicity to cancer cells. Additionally, the excimer fluorescence of BPC recovered after entering into the cancer cells, denoting the potential for real time tracking/visualization of drug delivery. The in vivo results also demonstrate that BPC NPs efficiently inhibited tumor growth without obvious systemic toxicity. As a novel Cu²⁺ chelated polymeric nanomaterial responsive to TME, BPC NPs show excellent potential in chemodynamic cancer therapy.

中文翻译：

苯并戊二烯接枝和Cu2 +螯合的聚合物纳米颗粒用于GSH耗竭和化学动力学治疗

可以响应特定肿瘤微环境（TME）的聚合物纳米粒子显示出巨大的潜力作为抗癌剂。在这项研究中，通过原子转移自由基聚合（ATRP）获得了高度水溶性的聚合物纳米粒子BPP 。接枝芳族苯并per的自聚集的强烈趋势促进了聚合物自组装成纳米颗粒。BPP表现出强烈的准分子发射，并可能与各种金属离子螯合，并具有猝灭发射。然后将Cu ²⁺与BPP螯合以形成BPC纳米颗粒，随后将其用作化学动力治疗剂。BPC进入癌细胞后，可以消耗GSH并产生Cu ⁺。Cu ⁺与细胞内H ₂反应O _2会通过Fenton样反应生成有毒的羟基自由基（˙OH），在TME中具有较快的反应速率。由于肿瘤细胞中高的GSH和H ₂ O ₂浓度，BPC NP对癌细胞具有选择性的细胞毒性。此外，BPC的准分子荧光在进入癌细胞后恢复，这表明了实时跟踪/可视化药物输送的潜力。该体内结果还证明，BPC的NP有效地抑制了肿瘤生长无明显的全身性毒性。作为对TME有反应的新型Cu ²⁺螯合聚合物纳米材料，BPC NP在化学动力癌症治疗中显示出极好的潜力。

更新日期：2021-01-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文