藏红花提取物对心血管疾病潜在氧化应激的有益作用,Oxidative Medicine and Cellular Longevity

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藏红花提取物对心血管疾病潜在氧化应激的有益作用
Oxidative Medicine and Cellular Longevity Pub Date : 2021-01-20 , DOI: 10.1155/2021/6699821
Xin Su ₁ , Chao Yuan ₂ , Li Wang ₃ , Runqi Chen ₄ , Xiangying Li ₃ , Yijun Zhang ₅ , Can Liu ₁ , Xu Liu ₆ , Wanping Liang ₅ , Yanwei Xing ₁

Affiliation

藏红花通常用于传统药物和珍贵香水。它含有具有显着抗氧化活性的药理活性化合物。藏红花含有多种活性成分，包括藏红花素、藏红花素和藏红花醛。氧化应激在许多心血管疾病中起着重要作用，其不受控制的连锁反应与心肌损伤有关。大量研究证实，藏红花对心肌具有保护作用，可能有益于治疗心血管疾病。鉴于氧化应激在心血管疾病中的作用，人们对藏红花提取物作为治疗一系列心血管疾病的潜在作用表现出相当大的兴趣。本综述从抗动脉粥样硬化、抗心肌缺血、抗缺血再灌注损伤、改善药物引起的心脏毒性，特别是蒽环类药物引起的心脏毒性四个方面分析了藏红花在抗氧化应激治疗心血管疾病中的应用。尽管人类数据有限，只有两项临床相关研究，但关于藏红花抗氧化应激作用的临床前研究结果很有希望，值得在临床试验中进一步研究。本综述总结了藏红花在心血管疾病和药物性心脏毒性中的保护作用。它将促进药理研究和开发，促进藏红花的利用。和改善药物引起的心脏毒性，特别是蒽环类药物引起的心脏毒性。尽管人类数据有限，只有两项临床相关研究，但关于藏红花抗氧化应激作用的临床前研究结果很有希望，值得在临床试验中进一步研究。本综述总结了藏红花在心血管疾病和药物性心脏毒性中的保护作用。它将促进药理研究和开发，促进藏红花的利用。和改善药物引起的心脏毒性，特别是蒽环类药物引起的心脏毒性。尽管人类数据有限，只有两项临床相关研究，但关于藏红花抗氧化应激作用的临床前研究结果很有希望，值得在临床试验中进一步研究。本综述总结了藏红花在心血管疾病和药物性心脏毒性中的保护作用。它将促进药理研究和开发，促进藏红花的利用。本综述总结了藏红花在心血管疾病和药物性心脏毒性中的保护作用。它将促进药理研究和开发，促进藏红花的利用。本综述总结了藏红花在心血管疾病和药物性心脏毒性中的保护作用。它将促进药理研究和开发，促进藏红花的利用。

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The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases

Saffron is commonly used in traditional medicines and precious perfumes. It contains pharmacologically active compounds with notably potent antioxidant activity. Saffron has a variety of active components, including crocin, crocetin, and safranal. Oxidative stress plays an important role in many cardiovascular diseases, and its uncontrolled chain reaction is related to myocardial injury. Numerous studies have confirmed that saffron exact exhibits protective effects on the myocardium and might be beneficial in the treatment of cardiovascular disease. In view of the role of oxidative stress in cardiovascular disease, people have shown considerable interest in the potential role of saffron extract as a treatment for a range of cardiovascular diseases. This review analyzed the use of saffron in the treatment of cardiovascular diseases through antioxidant stress from four aspects: antiatherosclerosis, antimyocardial ischemia, anti-ischemia reperfusion injury, and improvement in drug-induced cardiotoxicity, particularly anthracycline-induced. Although data is limited in humans with only two clinically relevant studies, the results of preclinical studies regarding the antioxidant stress effects of saffron are promising and warrant further research in clinical trials. This review summarized the protective effect of saffron in cardiovascular diseases and drug-induced cardiotoxicity. It will facilitate pharmacological research and development and promote utilization of saffron.

更新日期：2021-01-20

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