Orthogonal Control of DNA Nanoswitches with Mixed Physical and Biochemical Cues,Biochemistry

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Orthogonal Control of DNA Nanoswitches with Mixed Physical and Biochemical Cues
Biochemistry ( IF 2.9 ) Pub Date : 2021-01-19 , DOI: 10.1021/acs.biochem.0c00952
Nathan T Forrest ₁ , Javier Vilcapoma ₁ , Kristina Alejos ₁ , Ken Halvorsen ₁ , Arun Richard Chandrasekaran ₁

Affiliation

Nanoscale devices that can respond to external stimuli have potential applications in drug delivery, biosensing, and molecular computation. Construction using DNA has provided many such devices that can respond to cues such as nucleic acids, proteins, pH, light, or temperature. However, simultaneous control of molecular devices is still limited. Here, we present orthogonal control of DNA nanoswitches using physical (light) and biochemical (enzyme and nucleic acid) triggers. Each one of these triggers controls the reconfiguration of specific nanoswitches from locked to open states within a mixture and can be used in parallel to control a combination of nanoswitches. Such dynamic control over nanoscale devices allows the incorporation of tunable portions within larger structures as well as spatiotemporal control of DNA nanostructures.

中文翻译：

具有混合物理和生化线索的 DNA 纳米开关的正交控制

可以响应外部刺激的纳米级设备在药物输送、生物传感和分子计算方面具有潜在的应用。使用 DNA 的构建提供了许多可以对诸如核酸、蛋白质、pH、光或温度等线索作出反应的装置。然而，分子装置的同时控制仍然是有限的。在这里，我们使用物理（光）和生化（酶和核酸）触发器对 DNA 纳米开关进行正交控制。这些触发器中的每一个都控制混合物中特定纳米开关从锁定状态到打开状态的重新配置，并且可以并行使用以控制纳米开关的组合。这种对纳米级器件的动态控制允许将可调部分纳入更大的结构中，以及对 DNA 纳米结构的时空控制。

更新日期：2021-02-02

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