线粒体靶向 BODIPY 纳米颗粒用于增强体内光热和光声成像,ACS Applied Bio Materials

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线粒体靶向 BODIPY 纳米颗粒用于增强体内光热和光声成像
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-01-20 , DOI: 10.1021/acsabm.0c01509
Jiang-Lin Wang ₁ , Lu Zhang ₁ , Mei-Jiao Zhao ₂ , Tao Zhang ₂ , Yi Liu _{1,

3} , Feng-Lei Jiang ₁

Affiliation

短波长吸收和发射（<600 nm）、疏水性和低选择性极大地限制了 BODIPY 的生物医学应用。在此，一系列具有阳离子三苯膦 (TPP) 基团 ( Mito-BDP1-5 NPs) 的线粒体靶向 BODIPY 纳米颗粒带有不同长度的乙二醇（0-4 个单位），以及没有阳离子 TPP 基团的HO-BDP5比较，已经合理设计和准备研究它们的结构和相关特性之间的相互作用。我们的研究发现，Mito-BDP1-4 NPs 表现出聚集和沉淀的趋势，而Mito-BDP5 NPs 在水溶液中可以稳定。与HO-BDP5相比，量身定做Mito-BDP5具有 76.6 对 9.0% 的高光热转换效率 (PCE)，并表现出最高的光诱导细胞毒性。在 NIR 照射下， Mito-BDP5 NPs诱导的温度在 5 分钟内从室温迅速升高到体外 76.0°C 和体内肿瘤部位的 50.0°C。此外，还实现了有效的体外线粒体成像、光热成像（PTI）和体内光声成像（PAI）。在本文中，我们开发了针对线粒体并增强 PTI 和 PAI 性能的定制光热剂，可潜在应用于临床精密治疗学。

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Mitochondria-Targeted BODIPY Nanoparticles for Enhanced Photothermal and Photoacoustic Imaging In Vivo

Short-wavelength absorption and emission (<600 nm), hydrophobicity, and low selectivity have greatly restricted the biomedical applications of BODIPY. Herein, a series of mitochondria-targeted BODIPY nanoparticles with a cationic triphenylphosphine (TPP) group (Mito-BDP1-5 NPs) bearing different lengths of ethylene glycol (0–4 units), along with HO-BDP5 without a cationic TPP group for comparison, have been rationally designed and prepared to investigate the interplay between their structures and the related properties. Our studies found that Mito-BDP1-4 NPs showed a tendency of aggregation and precipitation while Mito-BDP5 NPs could be stable in aqueous solutions. Compared with HO-BDP5, tailor-made Mito-BDP5 possessed a high photothermal conversion efficiency (PCE) of 76.6 vs 9.0% and exhibited the highest photoinduced cytotoxicity. Upon NIR irradiation, the temperature induced by Mito-BDP5 NPs increased rapidly from room temperature to 76.0 °C in vitro and 50.0 °C at the tumor site in vivo within 5 min. Furthermore, effective mitochondrial imaging in vitro, photothermal imaging (PTI), and photoacoustic imaging (PAI) in vivo were achieved. In this paper, we developed tailor-made photothermal agents for targeting mitochondria and enhancing the PTI and PAI performances, which could be potentially applied in clinical precision theranostics.

更新日期：2021-02-15

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