European Polymer Journal ( IF 5.8 ) Pub Date : 2021-01-18 , DOI: 10.1016/j.eurpolymj.2020.110247
Burcu Acik , Gokhan Acik , Hamit Erdemi
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A series of environmentally friendly polyurethane (PU) films are successfully synthesized. For this purpose, ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) in the presence of cholic acid (CA) initiator, step-growth polymerization between achieved CA based poly (ε-caprolactone) (CA-PCL) and ʟ-Lysine diisocyanate ethyl ester (ʟ-LDI), and solution casting method were used, respectively. The effect of using different feeding ratios of ε-CL monomer (CA:ε-CL = 1:60, 1:75 and 1:90, by mole) on the properties of PUs are investigated in detail by fourier transform infrared (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopies, gel permeation chromatography (GPC), water contact angle (WCA) measurements, thermogravimetric and differential scanning calorimetry analyses (TGA and DSC) and mechanical tests, respectively. Moreover, biodegradation tests in the absence or presence of porcine pancreatic lipase are conducted to determine the degradation behaviors of resulted PURs. It has been found that a higher proportion of ε-CL repeating units in the PU backbone cause the improvement in hydrophobicity, thermal and mechanical properties, while leading to the deterioration in degradation behavior. Furthermore, biodegradation studies have led to conclude that CA-PCL-PUs are more degradable in both hydrolytic and enzymatic media compared to PCL-PU synthesized without CA. This study proved to CA, PCL and ʟ-LDI based biodegradable PU films have great potential for application in particularly tissue engineering and wound dressing.
中文翻译:
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胆汁酸,聚(ε-己内酯)和γ-赖氨酸二异氰酸酯乙酯的聚氨酯的合成,表征及其生物降解性能的研究
成功合成了一系列环保聚氨酯(PU)薄膜。为此,在胆酸(CA)引发剂的存在下,ε-己内酯(ε-CL)的开环聚合(ROP),在基于CA的聚(ε-己内酯)(CA-PCL)之间逐步增长聚合和-赖氨酸二异氰酸酯乙酯(ʟ-LDI)分别采用溶液浇铸法。通过傅立叶变换红外光谱(FT-FT)详细研究了使用不同进料比的ε-CL单体(CA:ε-CL= 1:60、1:75和1:90,按摩尔计)对PU性能的影响。红外和质子核磁共振(1H NMR)光谱,凝胶渗透色谱(GPC),水接触角(WCA)测量,热重和差示扫描量热分析(TGA和DSC)和机械测试。此外,在不存在或存在猪胰脂肪酶的情况下进行生物降解测试,以确定所得PUR的降解行为。已经发现,PU主链中较高比例的ε-CL重复单元引起疏水性,热和机械性能的改善,同时导致降解行为的劣化。此外,生物降解研究得出的结论是,与不使用CA合成的PCL-PU相比,CA-PCL-PU在水解和酶促介质中都更易降解。这项研究向CA证明,