Ebselen-Agents for Sensing, Imaging and Labeling: Facile and Full-Featured Application in Biochemical Analysis,ACS Applied Bio Materials

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Ebselen-Agents for Sensing, Imaging and Labeling: Facile and Full-Featured Application in Biochemical Analysis
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-01-16 , DOI: 10.1021/acsabm.0c01561
Jiawei Zhang ₁ , Lei Yang ₁ , Yuxin Wang ₁ , Tianyi Cao ₁ , Zhiwei Sun ₁ , Jie Xu ₂ , Yuxia Liu ₃ , Guang Chen _{1,

2}

Affiliation

Phenyl-1,2-benzoselenazol-3(2H)-one (ebselen) is a classical mimic of glutathione peroxidase (GPx). Thioredoxin interaction endows ebselen attractive biological functions, such as antioxidation and anti-infection, as well as versatile therapeutic usage. Accordingly, application of ebselen analogues in biosensing, chemical labeling, imaging analysis, disease pathology, drug development, clinical treatment, etc. have been widely developed, in which mercaptans, reactive oxygen species, reactive sulfur species, peptides, and proteins were involved. Herein, focusing on the application of ebselen-agents in biochemistry, we have made a systematic summary and comprehensive review. First, we summarized both the classical and the innovative methods for preparing ebselen-agents to present the synthetic strategies. Then we discussed the full functional applicability of ebselen analogues in three fields of biochemical analysis including the fluorescence sensing and bioimaging, derivatization for high throughput fluorescence analysis, and the labeling gents for proteomics. Finally, we discussed the current challenges and perspectives for ebselen-agents as analytical tools in biological research. By presenting the multifunctional applicability of ebselen, we hope this review could appeal researchers to design the ebselen-related biomaterials for biochemical analysis.

中文翻译：

Ebselen-Agents for Sensing, Imaging and Labels: 在生化分析中的简便和全功能应用

Phenyl-1,2-benzoselenazol-3(2H)-one (ebselen) 是谷胱甘肽过氧化物酶 (GPx) 的经典模拟物。硫氧还蛋白相互作用赋予依布硒啉有吸引力的生物学功能，例如抗氧化和抗感染，以及多种治疗用途。因此，依布硒啉类似物在生物传感、化学标记、影像分析、疾病病理学、药物开发、临床治疗等方面的应用得到广泛发展，其中涉及硫醇、活性氧、活性硫、肽和蛋白质。在此，我们就依布硒啉类药物在生物化学中的应用进行了系统总结和综合综述。首先，我们总结了制备依布硒啉的经典和创新方法，以提出合成策略。然后我们讨论了依布硒啉类似物在三个生化分析领域的全功能适用性，包括荧光传感和生物成像、高通量荧光分析的衍生化以及蛋白质组学的标记试剂。最后，我们讨论了依布硒啉作为生物研究分析工具的当前挑战和前景。通过展示依布硒啉的多功能适用性，我们希望这篇综述能够吸引研究人员设计用于生化分析的依布硒啉相关生物材料。我们讨论了依布硒啉作为生物研究分析工具的当前挑战和前景。通过展示依布硒啉的多功能适用性，我们希望这篇综述能够吸引研究人员设计用于生化分析的依布硒啉相关生物材料。我们讨论了依布硒啉作为生物研究分析工具的当前挑战和前景。通过展示依布硒啉的多功能适用性，我们希望这篇综述能够吸引研究人员设计用于生化分析的依布硒啉相关生物材料。

更新日期：2021-03-15

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