Dicer‐independent snRNA/snoRNA‐derived nuclear RNA 3 regulates tumor‐associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription,Cancer Communications

当前位置： X-MOL 学术 › Cancer Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dicer‐independent snRNA/snoRNA‐derived nuclear RNA 3 regulates tumor‐associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription
Cancer Communications ( IF 20.1 ) Pub Date : 2021-01-17 , DOI: 10.1002/cac2.12131
Yang Shi ₁ , Qingzhu Shi ₁ , Qicong Shen ₂ , Qian Zhang ₂ , Xuetao Cao _{1,

2,

3}

Affiliation

Small RNAs (sRNAs) extensively mediate gene‐specific chromatin regulation in lower organisms. As a dominant type of functional sRNAs in mature mammals, microRNAs mainly regulate gene expression at post‐transcription level in the cytoplasm. Currently, whether there exists a type of nuclear‐localized sRNAs mediating gene‐specific epigenetic regulation in mature mammalian cells remains largely unclear. Here, we profiled sRNAs enriched in the nucleus and investigated their function in mediating gene‐specific epigenetic regulation in anti‐tumor immunity.

中文翻译：

Dicer独立的snRNA/snoRNA衍生的核RNA 3通过表观遗传抑制诱导型一氧化氮合酶转录来调节肿瘤相关巨噬细胞功能

小RNA (sRNA) 广泛介导低等生物体中基因特异性染色质调控。作为成熟哺乳动物中功能性sRNA的主要类型，microRNA主要在细胞质的转录后水平调节基因表达。目前，成熟哺乳动物细胞中是否存在介导基因特异性表观遗传调控的核定位 sRNA 尚不清楚。在这里，我们分析了细胞核中富集的 sRNA，并研究了它们在介导抗肿瘤免疫中基因特异性表观遗传调控中的功能。

更新日期：2021-02-21

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文