Core–shell-Structured ZIF-8@PDA-HA with Controllable Zinc Ion Release and Superior Bioactivity for Improving a Poly-l-lactic Acid Scaffold,ACS Sustainable Chemistry & Engineering

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Core–shell-Structured ZIF-8@PDA-HA with Controllable Zinc Ion Release and Superior Bioactivity for Improving a Poly-l-lactic Acid Scaffold
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2021-01-15 , DOI: 10.1021/acssuschemeng.0c08009
Cijun Shuai _{1,

2,

3} , Jun Zan ₁ , Fang Deng ₁ , Youwen Yang _{1,

4} , Shuping Peng _{5,

6} , Zhenyu Zhao ₃

Affiliation

Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are able to act as effective reinforcements to enhance the overall performance of a poly-l-lactic acid (PLLA) scaffold due to its interface compatibility and natural degradability. Nevertheless, the fast degradation of ZIF-8 would release excessive zinc ions, which produces adverse effects on natural cell growth. In this study, a core–shell-structured nanoparticle, in which ZIF served as a core and hydroxyapatite (HA) served as a shell, was constructed by polydopamine (PDA)-induced in situ growth of HA on ZIF-8 nanoparticles, aiming to control the zinc ion release. Then, the core–shell-structured nanoparticle (ZIF-8@PDA-HA) was introduced into the PLLA scaffold using selective laser sintering. Results showed that the zinc ion concentration for the PLLA/ZIF-8@PDA-HA scaffold decreased by 65.3% after 28 days of immersion, as compared with the PLLA/ZIF-8 scaffold. Moreover, the in situ-synthesized HA possessed superior bioactivity, which effectively enhanced the mineralization ability of scaffolds and promoted cell adhesion, proliferation, and differentiation.

中文翻译：

核-壳结构的ZIF-8 @ PDA-HA具有可控的锌离子释放和卓越的生物活性，可改善聚L-乳酸支架

沸石咪唑酯骨架-8（ZIF-8）纳米颗粒能够作为有效增强材料以增强聚的整体性能升-乳酸（PLLA）支架，由于其界面相容性和自然可降解性。然而，ZIF-8的快速降解将释放过量的锌离子，这会对自然细胞生长产生不利影响。在这项研究中，通过聚多巴胺（PDA）诱导HA在ZIF-8纳米颗粒上原位生长，构建了以ZIF为核心和羟基磷灰石（HA）为壳的核-壳结构纳米颗粒。控制锌离子的释放。然后，使用选择性激光烧结将核壳结构的纳米粒子（ZIF-8 @ PDA-HA）引入PLLA支架中。结果显示，与PLLA / ZIF-8支架相比，浸泡28天后PLLA / ZIF-8 @ PDA-HA支架的锌离子浓度降低了65.3％。此外，原位合成的HA具有出色的生物活性，

更新日期：2021-02-01

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