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M351‐0056 is a novel low MW compound modulating the actions of the immune‐checkpoint protein VISTA
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2021-01-15 , DOI: 10.1111/bph.15357
Xinlei Hu 1 , Chenxin Qie 1 , Jingwei Jiang 1 , Xiaoxue Xie 1 , Wenting Chen 1 , Wanmei Liu 1 , Jun Liu 1
Affiliation  

The protein V‐domain immunoglobulin suppressor of T‐cell activation (VISTA) is a novel immune‐checkpoint molecule that belongs to the B7 family and regulates a broad spectrum of immune responses. So far, low MW compounds targeting VISTA for the treatment of autoimmune diseases or inflammation, have not been identified.

中文翻译:

M351-0056 是一种新型低分子量化合物,可调节免疫检查点蛋白 VISTA 的作用

T 细胞活化蛋白 V 域免疫球蛋白抑制因子 (VISTA) 是一种新型免疫检查点分子,属于 B7 家族,可调节广谱免疫反应。到目前为止,尚未确定针对 VISTA 治疗自身免疫性疾病或炎症的低分子量化合物。
更新日期:2021-02-28
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