基于三维框架的多功能纳米药物用于靶向光化学协同性癌症治疗,Advanced Healthcare Materials

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基于三维框架的多功能纳米药物用于靶向光化学协同性癌症治疗
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-01-14 , DOI: 10.1002/adhm.202001874
Enyun Xing ₁ , Yingying Du ₁ , Juanjuan Yin ₁ , Minghui Chen ₁ , Mengyao Zhu ₁ , Xiaona Wen ₂ , Jialiang Xu ₃ , Yaqing Feng _{1,

4} , Shuxian Meng ₁

Affiliation

靶向协同治疗在肿瘤治疗中具有广阔的前景。在此，基于三种传统抗癌药物（阿霉素（DOX），顺铂（CDDP）和甲氨蝶呤（MTX））修饰的氧化石墨烯（GDYO）的多功能纳米药物GDYO-CDDP / DOX @ DSPE-PEG-MTX（GCDM）是描述用于诊断和靶向癌症的光化学协同治疗。在该系统中，这三种传统的抗癌药物首次发挥了新的作用，并可以通过协同的抗肿瘤作用降低多药耐药性。顺铂可以与GDYO杂交形成一个多功能且分散良好的三维框架，该框架不仅可以用作纳米药物载体以实现高载药率（40.3％），而且还具有出色的光热转化效率（47）％）和在NIR辐照下具有良好的光动力效应。π - π堆叠，用作抗癌药和纳米药物检测的荧光探针。甲氨蝶呤（MTX）可用于靶向肿瘤，并在与DOX和CDDP协同化疗中发挥作用。合成的多功能纳米药物GCDM具有良好的生物相容性，主动靶向，长期保留，持续药物释放，出色的荧光成像功能以及显着的光化学协同治疗效果。

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Multi‐functional Nanodrug Based on a Three‐dimensional Framework for Targeted Photo‐chemo Synergetic Cancer Therapy

Targeted synergistic therapy has broad prospects in tumor treatments. Here, a multi‐functional nanodrug GDYO‐CDDP/DOX@DSPE‐PEG‐MTX (GCDM) based on three traditional anticancer drugs (doxorubicin (DOX), cisplatin (CDDP) and methotrexate (MTX)) modified graphdiyne oxide (GDYO) is described, for diagnosis and targeted cancer photo‐chemo synergetic therapy. In this system, for the first time, these three traditional anti‐cancer drugs have played new roles and can reduce multidrug resistance through synergistic anti‐tumor effects. Cisplatin can be hybridized with GDYO to form a multifunctional and well‐dispersed three‐dimensional framework, which can not only be used as nano‐drug carriers to achieve high drug loading rates (40.3%), but also exhibit excellent photothermal conversion efficiency (47%) and good photodynamic effects under NIR irradiation. Doxorubicin (DOX) is loaded onto GDYO‐CDDP through π‐π stacking, which is used as an anticancer drug and as a fluorescent probe for nanodrug detection. Methotrexate (MTX) can be applied in tumor targeting and play a role in synergistic chemotherapy with DOX and CDDP. The synthesized multi‐functional nanodrug GCDM has good biocompatibility, active targeting, long‐term retention, sustained drug release, excellent fluorescence imaging capabilities, and remarkable photo‐chemo synergistic therapeutic effects.

更新日期：2021-01-14

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