Intestinal immunoglobulin (Ig)A binds to distinct commensals and pathobionts, but do these IgA-coated bacterial communities define clinical characteristics of inflammatory disease? In this issue of Cell Host & Microbe, Shapiro et al. comprehensively analyze IgA-coated bacteria in new onset inflammatory bowel disease (IBD), revealing their potential in guiding precision therapy and diagnostic stratification.

中文翻译：

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钻石原石：IgA-Seq签名使新发病IBD分层

肠道免疫球蛋白（Ig）A与不同的肠膜和病原结合，但是这些IgA包被的细菌群落是否定义了炎症性疾病的临床特征？在本期《细胞宿主与微生物》中，Shapiro等人。对新发炎性肠病（IBD）中IgA包被的细菌进行了全面分析，揭示了它们在指导精确治疗和诊断分层方面的潜力。