Series of N'-(pyridine-3-ylmethylene)benzohydrazides 3a-y have been prepared by the condensation of nicotinaldehydes 1a-e with benzohydrazides 2a-e in the presence of glacial AcOH in ethanol at room temperature. Total twenty five compounds have been prepared and confirmed based on spectral data. The compounds have been evaluated for anti-microbial, free radical scavenging (DPPH, ABTS^.+) and α-glucosidase inhibitory activities. Compound 3h has shown potent anti-fungal activity. Compounds 3f-g and 3j have shown potent ABTS^.+ free radical scavenging activity. Compound 3d has shown potent anti-hyperglycemic activity.

中文翻译：

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烟醛与苯并肼的缩合反应可方便地合成N-（吡啶-3-基亚甲基）苯并肼

的系列Ñ “ - （吡啶-3-基亚甲基）benzohydrazides 3A-γ已经制备由nicotinaldehydes的缩合1A-E与benzohydrazides 2A-E在冰AcOH在乙醇存在下，在室温。总共制备了25种化合物，并根据光谱数据进行了确认。已经评估了该化合物的抗微生物，清除自由基（DPPH，ABTS ⁺）和α-葡萄糖苷酶抑制活性。化合物3h显示出有效的抗真菌活性。化合物3f-g和3j显示出有效的ABTS ⁺自由基清除活性。复合3d 已显示出有效的抗高血糖活性。