A simple and efficient method for the complementary and regioselective synthesis of isomeric 3-(isoxazol-5-yl)indoles and 3-(isoxazol-3-yl)indoles has been developed by the regioselective cyclocondensation reaction of β-ethylthio-β-indolyl-α,β-unsaturated ketones and hydroxylamine hydrochloride. It was found that the cyclocondensation reaction in the presence of excess NaOEt in refluxing EtOH gives 3-(isoxazol-5-yl)indoles in good yields, whereas using NaOAc in boiling AcOH gives 3-(isoxazol-3-yl)indoles in good yields.

中文翻译：

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由β-乙硫基-β-吲哚基-α，β-不饱和酮互补和区域选择性合成异构体3- [异恶唑-3（或5）-基]吲哚

通过β-乙硫基-β-吲哚基的区域选择性环缩合反应，开发了一种简单有效的方法，用于互补和区域选择性合成异构体3-（异恶唑-5-基）吲哚和3-（异恶唑-3-基）吲哚。 -α，β-不饱和酮和盐酸羟胺。已经发现，在过量的NaOEt存在下，在回流的EtOH中进行环缩合反应，可以得到高产率的3-（异恶唑-5-基）吲哚，而在沸腾的AcOH中使用NaOAc可以得到良好的3-（异恶唑-3-基）吲哚。产量。