Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties,Journal of the American Chemical Society

当前位置： X-MOL 学术 › J. Am. Chem. Soc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-01-11 , DOI: 10.1021/jacs.0c11641
Adam C Sedgwick ₁ , Kai-Cheng Yan ₂ , Daniel N Mangel ₁ , Ying Shang ₂ , Axel Steinbrueck ₁ , Hai-Hao Han ₂ , James T Brewster ₁ , Xi-Le Hu ₂ , Dylan W Snelson ₁ , Vincent M Lynch ₁ , He Tian ₂ , Xiao-Peng He ₂ , Jonathan L Sessler ₁

Affiliation

Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.

中文翻译：

Deferasirox (ExJade)：FDA 批准的具有独特光物理特性的 AIEgen 平台

Deferasirox (ExJade) 是 FDA 批准的铁螯合剂，用于治疗铁过载。在这项工作中，我们报告了几种荧光地拉罗司衍生物，它们显示出独特的光物理特性，即聚集诱导发射 (AIE)、激发态分子内质子转移、电荷转移以及水介质中的键合和空间共轭特性。地拉罗司支架上苯酚单元的功能化提供了荧光响应前螯合剂 ExPhos，它能够检测基于疾病的生物标志物碱性磷酸酶 (ALP)。这些地拉罗司衍生物的诊断潜力得到了细菌生物膜研究的支持。

更新日期：2021-01-11

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南