Fumonisin B1 (FB₁) is a toxic secondary metabolite produced by the Fusarium molds that can contaminate food and feed. It has been found that FB₁ can cause systemic toxicity, including neurotoxicity, hepatotoxicity, nephrotoxicity and mammalian cytotoxicity. This review addresses the toxicity studies carried out on FB₁ and outlines the probable mechanisms underlying its immunotoxicity, reproductive toxicity, joint toxicity, apoptosis, and autophagy. In the present work, the research progress of FB₁ detoxification in recent years is reviewed, which provides reference for controlling and reducing the toxicity of FB₁.

中文翻译：

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伏马菌素B ₁：动物的毒性和生物解毒进展机制

伏马菌素B1（FB ₁）是由镰刀霉菌产生的有毒次生代谢产物，可污染食物和饲料。已经发现FB ₁可以引起全身毒性，包括神经毒性，肝毒性，肾毒性和哺乳动物细胞毒性。这项审查解决了对FB ₁进行的毒性研究，并概述了其免疫毒性，生殖毒性，关节毒性，细胞凋亡和自噬的潜在机制。在目前的工作中，综述了近年来FB ₁解毒的研究进展，为控制和降低FB ₁的毒性提供了参考。