Bimetallic nanoparticles combined with 2D boron nitride shows an effective approach towards the fabrication of an efficient electrocatalyst with excellent physicochemical and electrochemical properties. This work describes the synthesis of iron vanadate nanoparticles (FeVO₄ NPs) supported on boron nitride (hBN) nanocomposite through hydrothermal synthesis followed by a solvent evaporation method for the ultra-sensitive electrochemical determination of chlorpromazine (CPZ). The nanocomposite was analyzed by typical characterization techniques such as X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscope (XPS), and Brunauer–Emmett–Teller (BET) analysis to confirm the crystalline phase, structural morphology, and surface area of the as-prepared nanocomposite. Under optimized voltammetric conditions, FeVO₄ NPs/30 hBN modified screen-printed carbon electrode (FeV NPs/30 hBN/SPCE) shows a wide linear concentration from 0.04 to 2222.1 μM, a lower detection limit of 0.004 μM with a sensitivity of 0.84 μA μM⁻¹ cm⁻². The as-proposed electrode demonstrated excellent stability, reproducibility, and selectivity in the presence of potentially interfering active compounds towards the detection of CPZ. Furthermore, the practicality was successfully demonstrated in human urine and serum samples with satisfactory results.

与2D氮化硼结合的双金属纳米粒子显示出一种有效的方法，可用于制造具有出色的物理化学和电化学性质的高效电催化剂。这项工作描述了钒酸铁纳米颗粒（FeVO ₄NPs）通过水热合成负载在氮化硼（hBN）纳米复合材料上，然后采用溶剂蒸发法进行氯丙嗪（CPZ）的超灵敏电化学测定。通过典型的表征技术，例如X射线衍射（XRD），傅立叶变换红外光谱（FT-IR），场发射扫描电子显微镜（FE-SEM），透射电子显微镜（TEM），X射线光电子，对纳米复合材料进行了分析。光谱仪（XPS）和Brunauer–Emmett–Teller（BET）分析，以确认所制备纳米复合材料的结晶相，结构形态和表面积。在优化的伏安条件下，FeVO ₄NPs / 30 hBN修饰的丝网印刷碳电极（FeV NPs / 30 hBN / SPCE）显示0.04至2222.1μM的宽线性浓度，0.004μM的较低检测限，灵敏度为0.84μAμM ^-1  cm ^-2。所提出的电极在存在可能干扰CPZ检测的活性化合物的情况下显示出极好的稳定性，可重复性和选择性。此外，已在人尿和血清样品中成功证明了实用性，并获得了令人满意的结果。