面向生物医学和农业食品分析应用的即时医疗服务（SERS）传感器：近期进展综述,Nanoscale

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面向生物医学和农业食品分析应用的即时医疗服务（SERS）传感器：近期进展综述
Nanoscale ( IF 5.8 ) Pub Date : 2020-12-8 , DOI: 10.1039/d0nr06832b
Jayakumar Perumal _{1,

2,

3,

4} , Yusong Wang _{1,

2,

3,

4} , Amalina Binte Ebrahim Attia _{1,

2,

3,

4} , U. S. Dinish _{1,

2,

3,

4} , Malini Olivo _{1,

2,

3,

4}

Affiliation

对生物化学传感中可靠而鲁棒的方法学的需求不断增长，要求传感器技术不断进步。在过去的二十年中，表面增强拉曼光谱法（SERS）成为生物医学和农业食品应用中敏感和痕量分析或检测的最有前途的分析技术之一。SERS克服了与拉曼光谱法相关的固有灵敏度限制，后者提供了分子的振动“指纹”光谱，使其在其他光谱学技术中独一无二且用途广泛。本文全面回顾了SERS在过去6年中在生物医学，食品和农业应用中的最新进展，并且我们认为在不久的将来，这些平台中的某些平台有可能被转换为现实生活中的最终用户应用程序的即时护理和快速传感器。基于诸如灵敏度，特异性，可用性，可重复性和再现性等关键特征，分析和讨论了各种SERS传感器设计的优缺点。最后，我们着重强调了该领域的机遇与挑战，同时强调了在实现针对实际生物医学和农业食品技术应用的商业可行的即时护理SERS传感器时需要解决的技术差距。

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Towards a point-of-care SERS sensor for biomedical and agri-food analysis applications: a review of recent advancements

The growing demand for reliable and robust methodology in bio-chemical sensing calls for the continuous advancement of sensor technologies. Over the last two decades, surface-enhanced Raman spectroscopy (SERS) has emerged as one of the most promising analytical techniques for sensitive and trace analysis or detection in biomedical and agri-food applications. SERS overcomes the inherent sensitivity limitation associated with Raman spectroscopy, which provides vibrational “fingerprint” spectra of molecules that makes it unique and versatile among other spectroscopy techniques. This paper comprehensively reviews the recent advancements of SERS for biomedical, food and agricultural applications over the last 6 years, and we envision that, in the near future, some of these platforms have the potential to be translated as a point-of-care and rapid sensor for real-life end-user applications. The merits and limitations of various SERS sensor designs are analysed and discussed based on critical features such as sensitivity, specificity, usability, repeatability and reproducibility. We conclude by highlighting the opportunities and challenges in the field while stressing the technological gaps to be addressed in realizing commercially viable point-of-care SERS sensors for practical biomedical and agri-food technological applications.

更新日期：2021-01-06

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