A novel, catalyst- and additive-free cascade phosphorylation/cyclization of readily available 2-propynolphenols with R₂P(O)OH (R = aryl, OPh, OBn) was developed for the construction of 2H-chromen-4-yl phosphinates/phosphonates and water as the only byproduct under mild conditions. The reaction was achieved by using R₂P(O)OH as acid-promoter, but also as the phosphinate source with the formation of phosphorylation allene intermediate, and followed by 6-endo-trig pathway. Additionally, this approach avoided the use of hazardous, air sensitive or activation reagents, and performed well with good functional group tolerance and satisfied yields.

开发了一种新颖的，无催化剂和无添加剂的，易于获得的2-丙炔酚与R ₂ P（O）OH（R ​​=芳基，OPh，OBn）的级联磷酸化/环化反应，用于构建2 H -chromen-4-yl次膦酸酯/膦酸酯和水是在温和条件下唯一的副产物。通过使用R ₂ P（O）OH作为酸促进剂，但也作为次膦酸酯源并形成磷酸化丙二烯中间体，并随后进行6-内-trig途径来实现反应。另外，该方法避免了使用危险的，对空气敏感的或活化的试剂，并且以良好的官能团耐受性和令人满意的产率表现良好。