Hydrogels, being highly biocompatible and adaptable with biological tissues, have shown great usability in biomedical applications. In this research, a novel hydrogel film developed from carboxymethyl chitosan (CMCS) loaded with waterborne polyurethane–gelatin hydrolysate was synthesized via aqueous emulsion copolymerization. The synthesized hydrogel film was characterized using mechanical strength tests, FTIR, XPS, SEM, AFM, and various other analysis technologies. The results demonstrated that the hydrogel film exhibited good thermal stability, swelling behavior, as well as controllable biodegradability. Specifically, when the CMCS content was loaded at 6 %, the maximum tensile strength and elongation at the break of the hydrogel film were reached 31.69 MPa and 447.187, respectively. The disk diffusion tests indicated that the hydrogel film presented significant antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). These results indicate that hydrogel films with high mechanical strength and high antibacterial activity could be used for wound dressing applications.

具有高度生物相容性且可与生物组织适应的水凝胶在生物医学应用中显示出极大的可用性。在这项研究中，通过水乳液共聚合成了一种载有水性聚氨酯-明胶水解物的羧甲基壳聚糖（CMCS）开发的新型水凝胶薄膜。使用机械强度测试，FTIR，XPS，SEM，AFM和其他各种分析技术对合成的水凝胶薄膜进行了表征。结果表明，水凝胶膜表现出良好的热稳定性，溶胀行为以及可控的生物降解性。具体地，当CMCS含量为6％时，水凝胶膜的最大抗张强度和断裂伸长率分别达到31.69MPa和447.187。大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）。这些结果表明具有高机械强度和高抗菌活性的水凝胶膜可用于伤口敷料应用。