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Iridium-Catalyzed Single-Step N-Substituted Lactam Synthesis from Lactones and Amines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2015-03-31 00:00:00 , DOI: 10.1021/acs.joc.5b00101
Kicheol Kim 1 , Soon Hyeok Hong 1
Affiliation  

Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformations—aminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamide—afforded the corresponding N-substituted lactams.

中文翻译:

内酯和胺催化铱催化的一步N取代内酰胺合成

使用Ir催化剂可直接由内酯和胺类催化合成内酰胺。三个连续的转化-内酯的氨基分解,胺与羟酰胺的N-烷基化以及氨基酰胺的分子内氨基转移-使相应的N-取代的内酰胺得到满足。
更新日期:2015-03-31
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