Background Serratia is an opportunistic pathogen known to cause an array of infectious presentations including UTIs, pneumonia, wound infections, skin and soft tissue infections, surgical site infections and although rare, endocarditis and bacteremia. The aim of the proposed study is to identify the characteristics of patients with community-acquired Serratia blood stream infection over a five-year period within the TriHealth inpatient population within the Cincinnati, Ohio Region. The study will also examine antibiotic resistance patterns among patients with Serratia bloodstream infections. Methods This is a retrospective cohort study of 107 adult patients admitted to two community hospitals from January 2014 to December 2018 with a positive blood culture for Serratia species. A complete data set of 100 patients was analyzed for complications, antibiotic resistance, in-hospital mortality, 90-day mortality, readmission within 90 days and length of Hospital Stay (LOS). Descriptive statistics was performed using frequencies for discrete variables and median (IQR) for continuous variables. Results Patients admitted with a positive Serratia blood culture were 38% female with a median (IQR) age of 54.5 years (40.25–71.75) and predominantly white (85%). Forty percent had hepatitis C (HCV) infection and 42% had a history of IV drug use. Most patients were living at home (77%), 18% in long term care and 91% were infected with Serratia marcescens. The most common complications were endocarditis (12%) and osteomyelitis (10%). Extended spectrum beta-lactamase (ESBL) production was confirmed in 13%. In-hospital mortality was 2%, 90-day mortality 2%, readmission 23% and median (IQR) LOS 7(3.25–14.75). PATIENT CHARACTERISTICS AND OUTCOMES (part 1) PATIENT CHARACTERISTICS AND OUTCOMES (part 2) PATIENT CHARACTERISTICS AND OUTCOMES (part 3) Conclusion This study demonstrates that a high proportion of patients admitted with Serratia bacteremia are IV drugs users and that they have a high prevalence of coexistent HCV infection. Endocarditis and metastatic foci of infection are relatively common. Appropriate empiric antibiotic management should take into account the significant incidence of ESBL production resulting in a prolonged LOS and a high readmission rate. Disclosures All Authors: No reported disclosures

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267. 沙雷氏菌血流感染特点及趋势

背景 沙雷氏菌是一种机会性病原体，已知会引起一系列感染性表现，包括尿路感染、肺炎、伤口感染、皮肤和软组织感染、手术部位感染，以及虽然罕见的心内膜炎和菌血症。拟议研究的目的是确定俄亥俄州辛辛那提地区 TriHealth 住院患者五年内社区获得性沙雷氏菌血流感染患者的特征。该研究还将检查沙雷氏菌血流感染患者的抗生素耐药性模式。方法 这是一项回顾性队列研究，纳入了 2014 年 1 月至 2018 年 12 月在两家社区医院收治的 107 名沙雷氏菌血培养阳性的成年患者。对包含 100 名患者的完整数据集进行并发症分析，抗生素耐药性、住院死亡率、90 天死亡率、90 天内再入院和住院时间 (LOS)。使用离散变量的频率和连续变量的中位数 (IQR) 进行描述性统计。结果 入院时沙雷氏菌血培养阳性的患者中 38% 为女性，中位 (IQR) 年龄为 54.5 岁 (40.25–71.75)，主要是白人 (85%)。40% 有丙型肝炎 (HCV) 感染，42% 有静脉注射药物使用史。大多数患者住在家里（77%），18% 接受长期护理，91% 感染了粘质沙雷氏菌。最常见的并发症是心内膜炎（12%）和骨髓炎（10%）。超广谱β-内酰胺酶（ESBL）的产量被证实为13%。住院死亡率为 2%，90 天死亡率为 2%，再入院率为 23%，中位 (IQR) LOS 为 7(3.25–14. 75)。患者特征和结果（第 1 部分） 患者特征和结果（第 2 部分） 患者特征和结果（第 3 部分）共存 HCV 感染。心内膜炎和感染转移灶比较常见。适当的经验性抗生素管理应考虑到 ESBL 产生的显着发生率，导致 LOS 延长和再入院率高。披露所有作者：没有报告披露 患者特征和结果（第 1 部分） 患者特征和结果（第 2 部分） 患者特征和结果（第 3 部分）共存 HCV 感染。心内膜炎和感染转移灶比较常见。适当的经验性抗生素管理应考虑到 ESBL 产生的显着发生率，导致 LOS 延长和再入院率高。披露所有作者：没有报告披露 患者特征和结果（第 1 部分） 患者特征和结果（第 2 部分） 患者特征和结果（第 3 部分）共存 HCV 感染。心内膜炎和感染转移灶比较常见。适当的经验性抗生素管理应考虑到 ESBL 产生的显着发生率，导致 LOS 延长和再入院率高。披露所有作者：没有报告披露 适当的经验性抗生素管理应考虑到 ESBL 产生的显着发生率，导致 LOS 延长和再入院率高。披露所有作者：没有报告披露 适当的经验性抗生素管理应考虑到 ESBL 产生的显着发生率，导致 LOS 延长和再入院率高。披露所有作者：没有报告披露