One-Pot Synthesis of 3-Substituted 4H-Quinolizin-4-ones via Alkyne Substrate Control Strategy,The Journal of Organic Chemistry

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One-Pot Synthesis of 3-Substituted 4H-Quinolizin-4-ones via Alkyne Substrate Control Strategy
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-12-29 , DOI: 10.1021/acs.joc.0c02484
Ji-Wang Fang _{1,

2} , Fang-Jie Liao ₂ , Yang Qian ₁ , Chao-Chen Dong _{1,

2} , Li-Jin Xu , Han-Yuan Gong

Affiliation

Three-substituted 4H-quinolizin-4-ones were obtained via a facile method with good selectivity and high efficiency. On the basis of alkyne substrate control, the mild and cost-efficient reaction has a broad substrate scope (20 examples, up to 93% yield) and is also easy to scale up. Active sites on the products allow for further modifications. The alkyne substrate control strategy could be further extended to achieve more complex three-substituted 4H-quinolizin-4-one skeletons.

中文翻译：

通过炔烃底物控制策略一锅法合成3取代的4 H-喹诺嗪4-酮

通过简便的方法以良好的选择性和高效率获得了三取代的4 H-喹啉嗪-4-酮。在炔烃底物控制的基础上，温和且经济高效的反应具有广泛的底物范围（20个实例，产率高达93％），并且也易于扩大规模。产品上的活动站点允许进一步修改。炔烃底物的控制策略可以进一步扩展，以实现更复杂的三取代的4 H -quinolizin-4-one骨架。

更新日期：2021-02-19

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