Cytotoxic Manoalide-Type Sesterterpenes from the Sponge Luffariella variabilis Collected in the South China Sea,Journal of Natural Products

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Cytotoxic Manoalide-Type Sesterterpenes from the Sponge Luffariella variabilis Collected in the South China Sea
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-12-28 , DOI: 10.1021/acs.jnatprod.0c01026
Xiangchao Luo _{1,

2} , Qi Wang _{1,

2,

3} , Xuli Tang ₄ , Jixiang Xu _{1,

2} , Mengxue Wang _{1,

2} , Pinglin Li _{1,

2} , Guoqiang Li _{1,

2}

Affiliation

Thirteen new linear terpenes, including 11 rare acyclic manoalide derivatives (1–11), one polyprenylphenol derivative (12), and one polyprenylbenzaldehyde derivative (13), together with three known compounds (14–16) were isolated from the sponge Luffariella variabilis collected in the South China Sea. The planar structures were resolved by NMR and MS analyses, while the absolute configurations were fully elucidated by NOESY experiments, combined with experimental and calculated ECD spectra, acetal formation, empirical rules of ¹H and ¹³C NMR shifts, DP4+ probability analyses, and Mosher’s method. Compounds 1–7, 10, and 13 demonstrated cytotoxic activities against several human cancer cell lines with IC₅₀ values ranging from 2 to 10 μM.

更新日期：2021-01-22

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