Synthesis of new metal‐free 1,2,4,5,9,10,12,13‐octaaza[16]annulene derivatives using the reaction of vinamidinium salts with thiocarbohydrazide,Journal of Heterocyclic Chemistry

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Synthesis of new metal‐free 1,2,4,5,9,10,12,13‐octaaza[16]annulene derivatives using the reaction of vinamidinium salts with thiocarbohydrazide
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-12-29 , DOI: 10.1002/jhet.4218
Askar Sabet ₁ , Abdolmohammad Mehranpour ₁

Affiliation

A new series of marcocyclic ligands, 1,2,4,5,9,10,12,13‐octaaza[16]annulene derivatives were synthesized by using the condensation reaction of the correspondingly [2+2] 2‐heteroaryl‐substituted vinamidinium salts or phenyl vinamidinium salts and derivatives or halo‐substituted vinamidinum salt [1A‐10A] with thiocarbohydrazide in ethanolic medium under mild condition. Metal complexes were formed by reacting of ethanolic solution of Co, Ni, and Zn with macrocyclic ligand in ethanolic medium under mild condition. Purposed complexes have been characterized with the help of elemental analyses, comparative absorption band of ν(C=N), mass, and NMR. Geometry and complex formulation are out of scope of this work. The biological activities of carohydrazide and thiocarbohydrazide base of the ligands and purposed complexes such as antimicrobial, antitumor, and insecticides have attracted significant attention in bioorganic chemistry.

中文翻译：

胺盐与硫代碳酰肼的反应合成新的无金属的1,2,4,5,9,10,12,13-辛基氮杂[16]环戊烯衍生物

利用相应的[2 + 2] 2-杂芳基取代的钒酰胺的缩合反应，合成了一系列新的大环配体1,2,4,5,9,10,12,13-辛基氮杂[16]在温和的条件下，在乙醇介质中与硫代碳酰肼一起制得的盐或苯基vinamidinium盐及其衍生物或卤素取代的vinamidinum盐[1A-10A]。金属配合物是在温和条件下，使Co，Ni和Zn的乙醇溶液与大环配体在乙醇介质中反应形成的。借助元素分析，ν（C = N）的比较吸收带，质量和NMR对目标配合物进行了表征。几何形状和复杂的公式超出了这项工作的范围。配体和特定复合物（如抗菌剂，抗肿瘤剂，

更新日期：2021-03-02

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