The synthetic proficiency of transition metal-catalyzed functionalization of dormant C-H bonds has established it as one of the leading methods for diversifying organic molecules. Palladium-based complexes are reckoned as front-runners for this purpose, primarily due to their low activation barrier during redox state shuffling. Despite the advances, exquisite stereoselective C-H activation remains a synthetic issue for Pd-catalysts. Incorporating interactive directing groups in the catalyst architecture has allowed leeway for selective functionalization of desired C-H bonds. Hence, the introduction of organopalladium catalysts has shifted the C-H activation chemistry paradigm through the catalytic cycle’s rational modulation. This review presents a comprehensive analysis of such organopalladium intermediates involved in site-selective C(sp³)-H functionalizations, emphasizing their intricate structure–function relationships.

过渡金属催化的休眠CH键官能化的合成能力已将其确立为使有机分子多样化的主要方法之一。为此，钯基络合物被认为是领跑者，这主要是由于其在氧化还原状态改组过程中的低活化势垒。尽管取得了进步，但对于Pd催化剂而言，精致的立体选择性CH活化仍然是一个合成问题。在催化剂结构中引入相互作用的导向基团已经为所需的CH键的选择性官能化留有余地。因此，有机钯催化剂的引入已经通过催化循环的合理调节改变了CH活化化学范式。这篇评论介绍了这种与位点选择性C（sp ³）-H功能化，强调其复杂的结构-功能关系。