Flutamide (FLT) is a non-steroidal anti-androgen drug mainly used to treat prostate cancer. However, the overdosage of FLT may cause severe side effects. Therefore, it is highly desirable and holds great importance to develop a simple, selective, and sensitive platform for anticancer drug detection. In this work, manganese oxide supported on hexagonal boron nitride (Mn₂O₃@h-BN) nanocomposite was achieved via co-precipitation method followed by solvent evaporation technique, and their effective electroanalytical sensing towards FLT was studied. The structural and morphological analysis of as-prepared nanocomposite were characterized using various analytical techniques like X-ray diffraction, Fourier transform infrared spectroscopy, scanning, and transmission electron microscopy. Furthermore, their electrical and electrochemical behaviour were examined using electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry techniques. Compared to other modified electrodes, the Mn₂O₃@h-BN modified electrode displayed a higher cathodic current of −22.30 µA. Herein, the Mn₂O_3, with the support of h-BN played a dynamic role throughout the electrode surface with a synergic effect resulting in a cumulative increase of electrocatalytic activity. Under the optimized conditions, Mn₂O₃@h-BN modified electrode revealed a comprehensive linear range from 0.08 to 1940 µM and the lowest detection limit of (LoD) 0.008 µM with a sensitivity of 3.69 µA µM⁻¹ cm⁻². The fabricated electrode proved to be a promising electrocatalyst through selective anti-interference ability, commendable repeatability, reproducibility, and high stability. Finally, the proposed electrode was applied for the determination of FLT in urine samples with acceptable recovery values from 93 to 102%.

Flutamide（FLT）是一种非甾体类抗雄激素药物，主要用于治疗前列腺癌。但是，过量服用FLT可能会导致严重的副作用。因此，迫切需要开发一种简单，选择性和灵敏的抗癌药物检测平台，并且非常重要。在这项工作中，锰氧化物负载在六方晶系氮化硼（MN ₂ ö ₃ @的h-BN）纳米复合材料来实现通过共沉淀法，然后采用溶剂蒸发技术，研究了它们对FLT的有效电分析传感。使用各种分析技术，如X射线衍射，傅立叶变换红外光谱，扫描和透射电子显微镜，对制得的纳米复合材料的结构和形态进行了表征。此外，使用电化学阻抗谱，循环伏安法和差分脉冲伏安法技术检查了它们的电和电化学行为。与其他修饰电极相比，Mn ₂ O ₃ @ h-BN修饰电极显示出-22.30 µA的更高阴极电流。此处，Mn ₂ O _3，h-BN的支持下，在整个电极表面起着动态作用，并起协同作用，导致电催化活性的累积增加。在优化条件下，Mn ₂ O ₃ @ h-BN修饰电极的线性范围在0.08至1940 µM之间，最低检测限（LoD）为0.008 µM，灵敏度为3.69 µA µM ^-1 cm ^-2。通过选择性的抗干扰能力，值得称赞的可重复性，可重复性和高稳定性，证明了所制备的电极是一种有前途的电催化剂。最后，将建议的电极用于尿样中FLT的测定，回收率在93％至102％之间。