Sinonasal papillomas are characterized by their potential for frequent recurrences and malignant progression. Currently, the role of human papillomavirus (HPV) infection in sinonasal papillomas is unclear. A study was conducted to elucidate the impact of HPV infection on recurrence and malignant progression of sinonasal papillomas. One hundred and seven patients with 151 tumors could be examined. One hundred and one patients suffered from benign papilloma, mostly inverted papillomas (IP); six patients suffered from carcinomas in situ and squamous cell carcinomas (SCC) ex‐IP. Recurrent IP were more often HPV‐positive than non‐recurrent tumors (38.8% vs. 60%–65%). Low‐risk (LR) HPV infection (especially HPV 6) increased the risk of tumor recurrences (p = 0.0385 and p = 0.0556, respectively). IP and oncocytic papillomas (both lesions are known for their malignant potential) were more often high‐risk (HR) HPV‐positive (15.5% and 16.7%) than fungiform papilloma (which usually does not progress to carcinoma). CIS and SCC ex‐IP displayed higher HPV rates than benign IP (83.3% vs. 38.8%), especially higher rates of HR‐HPV (66.7% vs. 23.8%, p = 0.0415). Data from this study endorse the hypothesis that recurrence of sinonasal papillomas is promoted by LR‐HPV infection and that malignant progression of IP is promoted by HR‐HPV infection.

中文翻译：

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人乳头瘤病毒（HPV）对鼻窦乳头状瘤复发率和恶性进展的影响

鼻窦乳头状瘤的特征在于其潜在的频繁复发和恶性进展。目前，尚不清楚人乳头瘤病毒（HPV）感染在鼻窦乳头状瘤中的作用。进行了一项研究，以阐明HPV感染对鼻窦乳头状瘤复发和恶性进展的影响。可以检查一百零七名患有151个肿瘤的患者。一百零一例患有良性乳头状瘤，多数为倒置性乳头状瘤（IP）；6位患者患有原位癌和ex-IP鳞状细胞癌（SCC）。与非复发性肿瘤相比，复发性IP多为HPV阳性（38.8％vs. 60％–65％）。低风险（LR）HPV感染（尤其是HPV 6）增加了肿瘤复发的风险（p  = 0.0385和p 分别为0.0556）。与真菌样乳头状瘤（通常不会发展为癌）相比，IP和囊性乳头状瘤（两种病变均以其潜在的恶性而闻名）更常是高危（HR）HPV阳性（15.5％和16.7％）。CIS和SCC ex-IP的HPV率高于良性IP（83.3％比38.8％），尤其是HR-HPV率更高（66.7％vs. 23.8％，p  = 0.0415）。这项研究的数据支持以下假设：LR-HPV感染可促进鼻窦乳头状瘤的复发，而HR-HPV感染可促进IP的恶性进展。